Eric J HaasFrederick J AnguloJohn M McLaughlinEmilia AnisShepherd R SingerFarid KhanNati BrooksMeir SmajaGabriel MircusKaijie PanJo SouthernDavid L SwerdlowLuis JodarYeheskel LevySharon Alroy-PreisAuthors:
During the analysis period (Jan 24 to April 3, 2021), there were 232 268 SARS-CoV-2 infections, 7694 COVID-19 hospitalizations, 4481 severe or critical COVID-19 hospitalizations, and 1113 COVID-19 deaths in people aged 16 years or older. By April 3, 2021, 4 714 932 (72∙1%) of 6 538 911 people aged 16 years and older were fully vaccinated with two doses of BNT162b2. Adjusted estimates of vaccine effectiveness at 7 days or longer after the second dose were 95∙3% (95% CI 94∙9–95∙7; incidence rate 91∙5 per 100 000 person-days in unvaccinated vs 3·1 per 100 000 person-days in fully vaccinated individuals) against SARS-CoV-2 infection, 91∙5% (90∙7–92∙2; 40∙9 vs 1∙8 per 100 000 person-days) against asymptomatic SARS-CoV-2 infection, 97∙0% (96∙7–97∙2; 32∙5 vs 0∙8 per 100 000 person-days) against symptomatic COVID-19, 97∙2% (96∙8–97∙5; 4∙6 vs 0∙3 per 100 000 person-days) against COVID-19-related hospitalization, 97∙5% (97∙1–97∙8; 2∙7 vs 0∙2 per 100 000 person-days) against severe or critical COVID-19-related hospitalization, and 96∙7% (96∙0–97∙3; 0·6 vs 0·1 per 100 000 person-days) against COVID-19-related death. In all age groups, as vaccine coverage increased, the incidence of SARS-CoV-2 outcomes declined. 8006 of 8472 samples tested showed a spike gene target failure, giving an estimated prevalence of the B.1.1.7 variant of 94∙5% among SARS-CoV-2 infections.