Not just antibodies: B cells and T cells mediate immunity to COVID-19


Authors: Rebecca J. Cox & Karl A. Brokstad Nature Reviews Immunology volume 20, pages581–582 (2020) Recent reports that antibodies to SARS-CoV-2 are not maintained in the serum following recovery from the virus have caused alarm. However,…[...]

Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence


Authors: Gemma E Hartley 1, Emily S J Edwards 1, Pei M Aui 1, Nirupama Varese 1 2, Stephanie Stojanovic 3, James McMahon 4 5, Anton Y Peleg 4 6, Irene Boo 7, Heidi E Drummer 7 8 9, P Mark Hogarth 1 10 11, Robyn E O'Hehir 1 2 3, Menno C van Zelm 12 2 Abstract Lasting immunity following SARS-CoV-2 infection…[...]

Antibody-dependent enhancement


Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into hostcells, followed by its replication.[1][2] ADE may cause enhanced respiratory disease and acute lung injury…[...]

SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy


Authors: C. Ferreras1†, B. Pascual-Miguel1†, C. Mestre-Durán1, A. Navarro-Zapata1, L. Clares-Villa1, C. Martín-Cortázar1, R. De Paz2, A. Marcos2, J. L. Vicario3, A. Balas3, F. García-Sánchez3, C. Eguizabal4,5, C. Solano6, M. Mora-Rillo7, B. Soria8,9 and A. Pérez-Martínez1,10,11* Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak…[...]