‘Visionary’ study finds inflammation, evidence of Covid virus years after infection


By Isabella Cueto, 2024 Stat Reporting Remember when we thought Covid was a two-week illness? So does Michael Peluso, assistant professor of medicine at the University of California, San Francisco.  He recalls the rush to study acute Covid infection, and the crush of resulting papers. But Peluso, an HIV researcher, knew what his team excelled at: following […]

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics


Rik G. H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, et. al.Nature (2024) Abstract The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, […]

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches


Roxana Gheorghita1,2Iuliana Soldanescu3Andrei Lobiuc2 , et. al., Front. Immunol., 03 March 2024, Sec. Viral Immunology, Volume 15 – 2024 | https://doi.org/10.3389/fimmu.2024.1344086 The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with the virus, a significant […]

Covid-19 has changed and so has our immunity. Here’s how to think about risk from the virus now


By Brenda Goodman, CNN August 28, 2023 Experts say it’s less risky to catch Covid-19 than it used to be, but there are still good reasons not to treat it casually. Daly and Newton/The Image Bank RF/Getty ImagesCNN —  Covid-19 was never just another cold. We knew it was going to stick around and keep changing to try to […]

Why Loss of Smell Can Persist After COVID-19


Research suggests that long-term smell loss is linked to an ongoing immune response in the nose By DUKE HEALTH NEWS OFFICE  Research This article is part of Harvard Medical School’s continuing coverage of COVID-19. New research has provided important insight into why some people fail to fully regain their sense of smell even months after recovering from COVID-19. […]

What Happens When You Still Have Long COVID Symptoms?


BY KATHY KATELLA OCTOBER 27, 2023, Yale Medicine Yale’s Long COVID program aims to treat patients with lingering COVID-19 symptoms, such as fatigue, brain fog, and shortness of breath. Note: Information in this article was accurate at the time of original publication. Because information about COVID-19 changes rapidly, we encourage you to visit the websites of the […]

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs


Jean-Laurent Casanova1,2,3,4,5 and Mark S. Anderson6,7, Published February 1, 2023 – More infoView PDF Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were discovered in 2006, but not […]

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines 


Sandhya Bansal; Sudhir Perincheri; Timothy Fleming; Christin Poulson;Brian Tiffany;Ross M. Bremner; Thalachallour Mohanakumar  J Immunol (2021) 207 (10): 2405–2410.https://doi.org/10.4049/jimmunol.2100637 Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity. To determine the mechanism, we analyzed the kinetics […]

Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases


Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox & Avik Roy  Infectious Agents and Cancer volume 18, Article number: 7 (2023) Cite this article, A Correction to this article was published on 24 April 2023 Abstract Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze […]

Unraveling long COVID: Here’s what scientists who study the illness want to find out


September 9, 2023, By Will Stone NPR Newsletter Researchers looking for root causes of long COVID work in the autopsy suite inside the Clinical Center at the National Institute of Health in Bethesda, Maryland. Valerie Plesch/Bloomberg via Getty Images For people suffering from long COVID’s often disabling symptoms, including intense fatigue, breathing troubles, cognitive issues and heart […]