Category: T-cell

CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease 

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Abstract Immune response dysregulation plays a key role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. In this study, we evaluated immune and endothelial blood cell profiles of patients…[...]

A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice

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Jide Tian1*Barbara J. Dillion2Jill Henley3et. al. Gamma-aminobutyric acid (GABA) and GABA-receptors (GABA-Rs) form a major neurotransmitter system in the brain. GABA-Rs are also expressed by 1) cells of the innate…[...]

‘Visionary’ study finds inflammation, evidence of Covid virus years after infection

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By Isabella Cueto, 2024 Stat Reporting Remember when we thought Covid was a two-week illness? So does Michael Peluso, assistant professor of medicine at the University of California, San Francisco.  He recalls…[...]

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

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Rik G. H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, et. al.Nature (2024) Abstract The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to…[...]

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

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Roxana Gheorghita1,2Iuliana Soldanescu3Andrei Lobiuc2 , et. al., Front. Immunol., 03 March 2024, Sec. Viral Immunology, Volume 15 - 2024 | https://doi.org/10.3389/fimmu.2024.1344086 The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has…[...]

Covid-19 has changed and so has our immunity. Here’s how to think about risk from the virus now

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By Brenda Goodman, CNN August 28, 2023 Experts say it’s less risky to catch Covid-19 than it used to be, but there are still good reasons not to treat it casually. Daly…[...]

What Happens When You Still Have Long COVID Symptoms?

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BY KATHY KATELLA OCTOBER 27, 2023, Yale Medicine Yale’s Long COVID program aims to treat patients with lingering COVID-19 symptoms, such as fatigue, brain fog, and shortness of breath. Note: Information in…[...]

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs

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Jean-Laurent Casanova1,2,3,4,5 and Mark S. Anderson6,7, Published February 1, 2023 - More infoView PDF Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe…[...]

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines 

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Sandhya Bansal; Sudhir Perincheri; Timothy Fleming; Christin Poulson;Brian Tiffany;Ross M. Bremner; Thalachallour Mohanakumar  J Immunol (2021) 207 (10): 2405–2410.https://doi.org/10.4049/jimmunol.2100637 Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory…[...]