Category: Immune System

SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow

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Isabelle Allaeys, Guillaume Lemaire, Mickaël Leclercq, et. al. Blood Adv (2024) 8 (11): 2777–2789. Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow (BM) and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence MK transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated […]

New study reveals insights into COVID-19 antibody response durability

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University of Maryland School of Medicine, 2024 Researchers at the Institute of Human Virology (IHV) at the University of Maryland School of Medicine have published a new study in the Journal of Infectious Diseases investigating the antibody response following SARS-CoV-2 infection. Long-lived plasma cells are responsible for durable antibody responses that persist for decades after immunization or infection. For example, infection […]

Understanding long COVID: A call for better diagnosis and treatment

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By Vijay Kumar Malesu,Mar 7 2024 In a recent review published in the journal Nature Reviews Microbiology, a group of authors summarized recent advancements in understanding long coronavirus disease (COVID) ‘s mechanisms, impacts, and research needs for better diagnostics and treatments. Review: Long COVID: major findings, mechanisms and recommendations Background Long COVID, affecting over 65 million globally, manifests through […]

People with Long COVID May Still Have Spike Proteins in Their Blood

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A possible biomarker for long COVID suggests some people with the condition never fully cleared the virus BY SASHA WARREN, Epidemiology; Scientific American The now infamous condition long COVID presents as a wide range of symptoms—everything from persistent chest pains to rashes, pins and needles, and brain fog. Doctors can diagnose long COVID by speaking to […]

CDC Claims On Vaccination And Natural Immunity Made Without Seeing Underlying Data: FOIA Document

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NOV 17, 2023 – Authored by Hans Mahncke via The Epoch Times  In a new Freedom of Information Act (FOIA) response, the Centers for Disease Control and Prevention (CDC) now admits that it recommended COVID-19 vaccines for people who had recovered from COVID-19 despite the fact that CDC subject matter experts didn’t have access to the […]

Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses

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Cutaneous Basophil Hypersensitivity Response after Skin-Test Antigen Injection. Philip W. Askenase, M.D., Yale University School of Medicine, New Haven, CT In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the […]

Unraveling long COVID: Here’s what scientists who study the illness want to find out

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September 9, 2023, By Will Stone NPR Newsletter Researchers looking for root causes of long COVID work in the autopsy suite inside the Clinical Center at the National Institute of Health in Bethesda, Maryland. Valerie Plesch/Bloomberg via Getty Images For people suffering from long COVID’s often disabling symptoms, including intense fatigue, breathing troubles, cognitive issues and heart […]

What you need to know about Covid as new variant rises

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September 24, 2023 BBC News Jim Reed The number of people in hospital has gone up. Google searches have doubled in a month and booster vaccines have been brought forward because of a new variant. It might all feel a bit 2021. But – these days – how much do we really need to worry […]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

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Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion of symptomatic patients with post-coronavirus 2019 (COVID-19) condition (long COVID) represents a significant burden on the individual as well as on the health care systems. […]

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines 

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Sandhya Bansal, Sudhir Perincheri, Timothy Fleming,Christin Poulson, Brian Tiffany, Ross M. Bremner;Thalachallour Mohanakumar Author & Article Information J Immunol (2021) 207 (10): 2405–2410. https://doi.org/10.4049/jimmunol.2100637 Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity. To determine the mechanism, we analyzed […]