Category: Adaptive Immunity

No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

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Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 – September 1, 2023. Reference information: J Clin Invest. 2023;133(17):e171742. https://doi.org/10.1172/JCI171742. To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune […]

Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases

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Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox & Avik Roy  Infectious Agents and Cancer volume 18, Article number: 7 (2023) Cite this article, A Correction to this article was published on 24 April 2023 Abstract Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze […]

Counties With Highest Vaccination Rates See More COVID-19 Cases Than Least Vaccinated

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Authors: Petr Svab April 4, 2022 Updated: April 5, 2022 THE EPOCH TIMES U.S. counties with the highest rates of vaccination against COVID-19 are currently experiencing more cases than those with the lowest vaccination rates, according to data collected by the Centers for Disease Control and Prevention (CDC). The 500 counties where 62 to 95 percent of the population has been […]

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

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Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Nature volume 595, pages421–425 (2021) Abstract Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies1,2,3,4,5,6,7. Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with […]

New York Times Admits Unvaxxed People Have ‘Lower Rates of Infection And Hospitalization’ Of COVID-19 Than The Vaxxed.

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Authors: Natalie Winters A January 19th update posted to the outlet’s COVID-19 live blog explains how unvaccinated individuals who previously contracted the virus “had lower rates of infection and hospitalization than those protected by vaccines alone”: During the week beginning May 30, 2021, vaccinated people who had not experienced Covid had the lowest risk of coronavirus infection […]

Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States

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Authors: S. V. Subramanian & Akhil Kumar  European Journal of Epidemiology (2021) Vaccines currently are the primary mitigation strategy to combat COVID-19 around the world. For instance, the narrative related to the ongoing surge of new cases in the United States (US) is argued to be driven by areas with low vaccination rates [1]. A similar narrative also has […]

‘Natural Immunity Is Really Better’: New Israeli Study Fuels Debate On Vaccination Versus Natural Immunity

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Authors: DYLAN HOUSMAN HEALTHCARE REPORTER August 28, 20215:12 PM ET A new study of the power of COVID-19 natural immunity versus the protection provided by vaccines is igniting further debate among scientists on how to assess risk from the virus. The observational study of more than 700,000 Israelis, which hasn’t yet been peer-reviewed, compared three groups: those […]

Why COVID-19 Is Here to Stay, and Why You Shouldn’t Worry About It

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Authors: August 17, 2021 by Philippe Lemoine As many countries are going through another wave of infections, including some where the vast majority of the population has been vaccinated, many are starting to despair that we’ll never see the end of the pandemic. In this post, I will argue that, on the contrary, not only is the […]

Trained Innate Immunity, Epigenetics, and Covid-19

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Authors: Alberto Mantovani, M.D., and Mihai G. Netea, M.D. Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in tissue repair and resistance against pathogens.1 Exposure to selected vaccines, such as bacille Calmette–Guérin (BCG) or microbial components, can increase the baseline tone of innate immunity and trigger […]

Adaptive immunity to SARS-CoV-2 and COVID-19

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Authors: Alessandro Sette1,2 and Shane Crotty1,2,* 1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA2Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA92037, USA SUMMARYThe adaptive immune system is important for control of most viral […]