Category: Mitochondrial Adapters MAVS

How Covid-19 damages lungs explained

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Authors: mINT oCTOBER 31, 2022 sYNOPSIS SARS-CoV-2 is the third novel coronavirus to cause human outbreaks in the 21st century, following SARS-CoV in 2003 and MERS-CoV in 2012. Covid-19: The virus attacks mitochondria, continuing an ancient battle that began in the primordial soup Kingston (Canada), (The Conversation): Viruses and bacteria have a very long history. […]

UniProtKB – P59636 (ORF9B_SARS)

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Protein: ORF9b protein database Gene: 9b Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli Functioni Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, […]