John Murphy, CEO, COVID-19 Long-haul Foundation Abstract Sleep disturbance has emerged as one of the most prevalent, persistent, and disabling manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), commonly known […]
Recognition of Long COVID as a Heterogeneous Post-Infectious Syndrome
Toward a Multisystem Endotype Framework for Post–Acute SARS-CoV-2 Disease John Murphy, M.D., M.P.H., D.P.H. President Covid-19 Long-haul Foundation Abstract Long COVID (post–acute sequelae of SARS-CoV-2 infection, PASC) has emerged as […]
Treatment Landscape in Long COVID Has Expanded Beyond “Supportive Care”
A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Mitochondrial Depletion and Long-COVID: Etiology, Pathophysiology, Diagnostics, and Clinical Implications
John Murphy, M.D., MPH, D.P.H., President The COVID19 Long-haul Foundation AbstractA growing body of evidence implicates mitochondrial dysfunction — including depletion of mitochondrial DNA (mtDNA), loss of mitochondrial membrane potential, […]
COVID Fatigue: Etiology, Genomics, Physiology, Pathology, Neurobiology, Sleep Disturbance, Treatment, and Prognosis
John Murphy, CEO COVID-19 Long-haul Foundation Abstract Fatigue is the most prevalent and disabling symptom among survivors of SARS‑CoV‑2 infection, persisting in a substantial proportion of patients months to years […]
COVID-19 and Cataractogenesis: Mechanistic Insights into Viral-Induced Ocular Pathology
Abstract Cataracts, the leading cause of blindness worldwide, are traditionally associated with aging, oxidative stress, and metabolic disorders. However, emerging evidence suggests that SARS-CoV-2 infection may accelerate or precipitate cataract […]
Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID
Andrea Polli, Lode Godderis, Dries S. Martens, et. al., , BMC Medicine volume 23, Article number: 60 (2025) Cite this article Abstract Background Long-COVID is defined as the persistency or development of new symptoms 3 months after the initial SARS-CoV-2 […]
Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations?
Christian A Koch, Journal of the Endocrine Society, Volume 8, Issue 5, May 2024, bvae043, https://doi.org/10.1210/jendso/bvae043 Commentary Approximately 5% of all individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) […]
Long COVID and brain inflammation: unravelling mechanisms and potential therapies
Fatemeh Saheb Sharif-Askari1,2*†Jacob Raber3*†Karem H. Alzoubi1,2 Patients with Long COVID often experience persistent brain-related symptoms, including brain fog, mood changes, and dizziness (1–3), likely driven by neuroinflammation even after the […]