By Social Links for Adriana Diaz Published Feb. 16, 2024, Extreme fatigue and difficulty exercising are common symptoms of long COVID — now scientists may finally have discovered why. While most people who test positive for the coronavirus are over their symptoms within a week or two, more research is showing that some people continue to report symptoms — […]
Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox & Avik Roy Infectious Agents and Cancer volume 18, Article number: 7 (2023) Cite this article, A Correction to this article was published on 24 April 2023 Abstract Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze […]
Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Cite this article 17 October 2022 Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that […]
With so many treatment candidates, researchers work to gain more clarity by Shi En Kim September 11, 2023 | A version of this story appeared in Volume 101, Issue 30 Hannah Davis misses her old self. Like so many people around the world, she has seen her life upended by long COVID, which has made many once-routine […]
Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]
Authors: mINT oCTOBER 31, 2022 sYNOPSIS SARS-CoV-2 is the third novel coronavirus to cause human outbreaks in the 21st century, following SARS-CoV in 2003 and MERS-CoV in 2012. Covid-19: The virus attacks mitochondria, continuing an ancient battle that began in the primordial soup Kingston (Canada), (The Conversation): Viruses and bacteria have a very long history. […]
An Attack on Mitochondria? Authors: MAGGIE RYAN February 2, 2022 As the pandemic continues, long COVID-19 remains very prevalent (affecting between 31 and 69 percent of COVID-19 patients) and somewhat bewildering because there’s no clear connection between the severity of a patient’s initial symptoms and how long they might linger. That was one thing that Irina Petrache, MD, chief of the […]
Authors: Davide Scozzi,1Marlene Cano,2Lina Ma,2Dequan Zhou,1Ji Hong Zhu,1Jane A. O’Halloran,3Charles Goss,4Adriana M. Rauseo,3Zhiyi Liu,1Sanjaya K. Sahu,2Valentina Peritore,5Monica Rocco,6Alberto Ricci,7Rachele Amodeo,8Laura Aimati,8Mohsen Ibrahim,1,5Ramsey Hachem,2Daniel Kreisel,1Philip A. Mudd,9Hrishikesh S. Kulkarni,2,10 and Andrew E. Gelman1,11 Abstract Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict […]
Protein: ORF9b protein database Gene: 9b Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli Functioni Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, […]
.J Immunol 2014 Sep 15;193(6):3080-9. doi: 10.4049/jimmunol.1303196. Epub 2014 Aug 18. Chong-Shan Shi 1, Hai-Yan Qi 2, Cedric Boularan 1, Ning-Na Huang 1, Mones Abu-Asab 3, James H Shelhamer 2, John H Kehrl 4 Abstract Coronaviruses (CoV) have recently emerged as potentially serious pathogens that can cause significant human morbidity and death. The severe acute respiratory syndrome (SARS)-CoV was identified as the etiologic agent of the 2002-2003 international SARS outbreak. […]