A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Energy depletion in long-COVID: etiology, physiology, pathology, and clinical findings of exhaustion
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract Persistent, debilitating fatigue and exertional intolerance are among the most frequent and disabling features of post-acute sequelae of SARS-CoV-2 infection […]
Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations?
Christian A Koch, Journal of the Endocrine Society, Volume 8, Issue 5, May 2024, bvae043, https://doi.org/10.1210/jendso/bvae043 Commentary Approximately 5% of all individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) […]
Long COVID and brain inflammation: unravelling mechanisms and potential therapies
Fatemeh Saheb Sharif-Askari1,2*†Jacob Raber3*†Karem H. Alzoubi1,2 Patients with Long COVID often experience persistent brain-related symptoms, including brain fog, mood changes, and dizziness (1–3), likely driven by neuroinflammation even after the […]
🧪 COVID Spike Protein and Kidney Damage: Stage 3B Illness, Fluid Retention, and Electrolyte Recovery
As research into Long COVID and post-vaccination syndromes deepens, 2025 peer-reviewed studies have identified a troubling link between spike protein persistence and kidney damage, particularly in patients progressing to Stage […]
Long COVID: damaged mitochondria in muscles might be linked to some of the symptoms
Caroline Dalton, Associate Professor of Neuroscience and Genetics, Sheffield Hallam University It’s estimated around 3% of people in the UK experience long COVID – persistent, long-lasting symptoms after a COVID-19 infection. Long […]
Researchers discover that tiredness experienced by long COVID patients has a physical cause
by Amsterdam University Medical Center Researchers from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have discovered that the persistent fatigue in patients with long COVID has a biological cause, namely […]
Long COVID can destroy your ability to exercise or do simple tasks — now we may know why
By Social Links for Adriana Diaz Published Feb. 16, 2024, Extreme fatigue and difficulty exercising are common symptoms of long COVID — now scientists may finally have discovered why. While most people who test […]
Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases
Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox & Avik Roy Infectious Agents and Cancer volume 18, Article number: 7 (2023) Cite this article, A Correction to this article was published on 24 April 2023 Abstract Historically, COVID-19 emerges as one of […]