UniProtKB – P59636 (ORF9B_SARS)

Protein: ORF9b protein database

Gene: 9b

Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.1 Publication

Miscellaneous

The gene encoding this protein is included within the N gene (alternative ORF).

GO – Molecular functionⁱ

• identical protein binding Source: IntAct
• Complete GO annotation on QuickGO …

GO – Biological processⁱ

• suppression by virus of host MAVS activity Source: UniProtKB
• Complete GO annotation on QuickGO …

Keywordsⁱ

Biological process

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

For In-depth Information of ORF-9b Protein: https://www.uniprot.org/uniprot/P59636