Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19


Authors : Mirren Charnley, Saba Islam,  Guneet K. Bindra,  Jeremy Engwirda,  Julian Ratcliffe,  Jiangtao Zhou,  Raffaele Mezzenga,  Mark D. Hulett,  Kyunghoon Han,  Joshua T. Berryman & Nicholas P. Reynolds  Nature Communications volume 13, Article number: 3387 (2022)  July…[...]

Characteristics of SARS-CoV-2 and COVID-19


Authors: Ben Hu, Hua Guo, Peng Zhou & Zheng-Li Shi  Nature Reviews Microbiology volume 19, pages141–154 (2021) Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019…[...]

Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus


Authors: Igor Moshynskyy 1, Sathiyanarayanan Viswanathan, Natalia Vasilenko, Vladislav Lobanov, Martin Petric, Lorne A Babiuk, Alexander N Zakhartchouk Abstract Open reading frame 9b (ORF 9b) encodes a 98 amino acid group-specific protein of severe acute respiratory syndrome…[...]

The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus


Author links open overlay panelChristophMeier123A. RaduAricescu13ReneAssenberg2Robin T.Aplin2Robert J.C.Gilbert13Jonathan M.Grimes123David I.Stuart123 Summary To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is…[...]

SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the AVS/TRAF3/TRAF6 signalosome


.J Immunol 2014 Sep 15;193(6):3080-9. doi: 10.4049/jimmunol.1303196. Epub 2014 Aug 18. Chong-Shan Shi 1, Hai-Yan Qi 2, Cedric Boularan 1, Ning-Na Huang 1, Mones Abu-Asab 3, James H Shelhamer 2, John H Kehrl 4 Abstract Coronaviruses (CoV) have recently emerged as potentially serious pathogens that…[...]