Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

August 2, 2022 | John Murphy | Leave a Comment

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

Authors : Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirda, Julian Ratcliffe, Jiangtao Zhou, Raffaele Mezzenga, Mark D. Hulett, Kyunghoon Han, Joshua T. Berryman & Nicholas P. Reynolds Nature Communications volume 13, Article number: 3387 (2022) July…[...]

August 20, 2021 | John Murphy | Leave a Comment

Characteristics of SARS-CoV-2 and COVID-19

Authors: Ben Hu, Hua Guo, Peng Zhou & Zheng-Li Shi Nature Reviews Microbiology volume 19, pages141–154 (2021) Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019…[...]

August 17, 2021 | John Murphy | Leave a Comment

Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus

Authors: Igor Moshynskyy 1, Sathiyanarayanan Viswanathan, Natalia Vasilenko, Vladislav Lobanov, Martin Petric, Lorne A Babiuk, Alexander N Zakhartchouk Abstract Open reading frame 9b (ORF 9b) encodes a 98 amino acid group-specific protein of severe acute respiratory syndrome…[...]

August 17, 2021 | John Murphy | Leave a Comment

The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus

Author links open overlay panelChristophMeier123A. RaduAricescu13ReneAssenberg2Robin T.Aplin2Robert J.C.Gilbert13Jonathan M.Grimes123David I.Stuart123 Summary To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is…[...]

August 17, 2021 | John Murphy | Leave a Comment

UniProtKB – P59636 (ORF9B_SARS)

Protein: ORF9b protein database Gene: 9b Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli Functioni Plays a role in the inhibition of host innate…[...]

August 17, 2021 | John Murphy | Leave a Comment

SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the AVS/TRAF3/TRAF6 signalosome

.J Immunol 2014 Sep 15;193(6):3080-9. doi: 10.4049/jimmunol.1303196. Epub 2014 Aug 18. Chong-Shan Shi 1, Hai-Yan Qi 2, Cedric Boularan 1, Ning-Na Huang 1, Mones Abu-Asab 3, James H Shelhamer 2, John H Kehrl 4 Abstract Coronaviruses (CoV) have recently emerged as potentially serious pathogens that…[...]