Authors: Yuichiro J. Suzuki,a,⁎ Sofia I. Nikolaienko,b Vyacheslav A. Dibrova,b Yulia V. Dibrova,b Volodymyr M. Vasylyk,c Mykhailo Y. Novikov,d Nataliia V. Shults,a and Sergiy G. Gychkab Currently, the world is suffering from the pandemic of coronavirus disease 2019 […]
COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options
Authors: Larissa E van Eijk, 1 , † Mathijs Binkhorst, 2 , † Arno R Bourgonje, 3 , ‡ Annette K Offringa, 4 , ‡ Douwe J Mulder, 5 Eelke M Bos, 6 Nikola Kolundzic, 7 , 8 Amaal E Abdulle, 5 Peter HJ van der Voort, 9 Marcel GM Olde Rikkert, 10 Johannes G […]
Never ignore extremely elevated D-dimer levels: they are specific for serious illness
Authors: T Schutte 1, A Thijs, Y M Smulders D-dimer is routinely measured as part of the clinical diagnosis algorithms for venous thromboembolism (VTE). In these algorithms, low D- dimer cut-off values are […]
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis
Authors: Keshav K. Singh,* Gyaneshwer Chaubey,* Jake Y. Chen, and Prashanth Suravajhala Because of the ongoing pandemic around the world, the mechanisms underlying the SARS-CoV-2-induced COVID-19 are subject to intense investigation. Based on […]
COVID-19: A Mitochondrial Perspective
Authors: Pankaj Prasun 1 Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a […]
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis
Authors: Keshav K. Singh,* Gyaneshwer Chaubey,* Jake Y. Chen, and Prashanth Suravajhala Because of the ongoing pandemic around the world, the mechanisms underlying the SARS-CoV-2-induced COVID-19 are subject to intense investigation. Based on […]
COVID-19 Autopsies Put Endothelial Damage, Angiogenesis in the Spotlight
Authors: L.A. McKeown NEWSDaily News COVID-19 Autopsies Put Endothelial Damage, Angiogenesis in the Spotlight The still-forming picture suggests significantly more new-vessel growth in the lung than would be expected from […]
COVID-19 is, in the end, an endothelial disease
Authors: Peter Libby, Thomas Lüscher The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that normally maintain homeostasis. This tightly […]
COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury
Authors: Roberto F. Nicosia,∗∗ Giovanni Ligresti,† Nunzia Caporarello,‡ Shreeram Akilesh,∗ and Domenico Ribatti§ Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular complications characterized by thrombosis of small, medium, and large vessels. […]
Endothelial dysfunction in COVID-19: Current findings and therapeutic implications
Authors: Matthias P Nägele 1, Bernhard Haubner 1, Felix C Tanner 1, Frank Ruschitzka 1, Andreas J Flammer 2 Coronavirus disease 2019 (COVID-19) increases the risk of several non-pulmonary complications such as acute myocardial injury, renal failure or thromboembolic […]