Category: Treatments

COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment

Posted on | Posted on John Murphy | Leave a Comment on COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment

Authors: Anant Parasher Abstract Background The severe acute respiratory syndrome (SARS) coronavirus-2 is a novel coronavirus belonging to the family Coronaviridae and is now known to be responsible for the outbreak of a series of recent acute atypical respiratory infections originating in Wuhan, China. The disease caused by this virus, termed coronavirus disease 19 or simply […]

The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review

Posted on | Posted on John Murphy | Leave a Comment on The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review

Authors: Shiqian Huang, Shuai Zhao, Huilin Luo, Zhouyang Wu, Jing Wu, Haifa Xia & Xiangdong Chen BMC Pulmonary Medicine volume 21, Article number: 116 (2021) Abstract Extracorporeal life support treatments such as extracorporeal membrane oxygenation (ECMO) have been recommended for the treatment of severe acute respiratory distress syndrome (ARDS) patients with coronavirus disease 2019 (COVID-19). To date, many countries, including China, have adopted ECMO as a treatment for […]

COVID-19 pathophysiology: A review

Posted on | Posted on John Murphy | Leave a Comment on COVID-19 pathophysiology: A review

Authors: COVID-19 pathophysiology: A review Koichi Yuki,⁎ Miho Fujiogi, and Sophia Koutsogiannaki Abstract In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused by this virus was termed COVID-19. The virus is transmittable between humans and has caused pandemic worldwide. The […]

Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

Posted on | Posted on John Murphy | Leave a Comment on Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

Authors: Andrew F. Read ,Susan J. Baigent,Claire Powers,Lydia B. Kgosana,Luke Blackwell,Lorraine P. Smith,David A. Kennedy,Stephen W. Walkden-Brown,Venugopal K. Nair Abstract Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission […]

How To Increase Platelet Count In COVID Patients? What Is Thrombocytopenia?

Posted on | Posted on John Murphy | Leave a Comment on How To Increase Platelet Count In COVID Patients? What Is Thrombocytopenia?

Authors: Ananya Varma Platelets are said to play an important role in inflammatory signalling. Here is why it is important to keep a check of Platelet count in COVID patients.  Given that COVID-19 is a relatively novel disease, newer research continues to emerge into its characteristics with scientists now linking rapidly decreasing platelets to be a symptom of […]

Bell’s Palsy after second dose of Pfizer COVID-19 vaccination in a patient with history of recurrent Bell’s palsy

Posted on | Posted on John Murphy | Leave a Comment on Bell’s Palsy after second dose of Pfizer COVID-19 vaccination in a patient with history of recurrent Bell’s palsy

Authors: Michael Repajic,a Xue Lei Lai,a Prissilla Xu,b and Antonio Liua,∗ Abstract Objective To report a patient with history of recurrent Bell’s Palsy who developed Bell’s Palsy 36 ​h after the administration of the second dose of the Pfizer-BioNTech COVID-19 vaccine. Case The patient is a 57-year-old female with past medical history of 3 episodes of Bell’s Palsy. She responded […]

90% Of Patients Treated With Experimental Israeli COVID Drug Discharged Within 5 Days

Posted on | Posted on John Murphy | Leave a Comment on 90% Of Patients Treated With Experimental Israeli COVID Drug Discharged Within 5 Days

Authors: BY TYLER DURDEN Finally, it looks like the world might be on the verge of obtaining a therapeutic drug that’s actually effective at helping patients infected with COVID. But you probably won’t hear anything about this latest breakthrough from the American media, which covered the race for a vaccine with breathless enthusiasm. According to […]

How B cells fight the COVID-19 virus

Posted on | Posted on John Murphy | Leave a Comment on How B cells fight the COVID-19 virus

Authors: Sarah C.P. Williams A study of antibody-producing B cells from patients who recovered from COVID-19 reveals a new cross-reactive antibody and what makes some B cells more effective at neutralizing the virus. Inside the body of a person with COVID-19, the immune system’s B cells are engaged in a full-scale battle with the SARS-CoV-2 […]

Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

Posted on | Posted on John Murphy | Leave a Comment on Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

Authors: Bandar Alosaimi1,2, Ayman Mubarak3, Maaweya E. Hamed3, Abdullah Z. Almutairi4, Ahmed A. Alrashed5, Abdullah AlJuryyan6, Mushira Enani7,Faris Q. Alenzi8 and Wael Alturaiki9* COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve the complement pathway activation for cytokine storm development. Nevertheless, the role of complement in COVID-19 immunopathology, complement‐modulating treatment strategies against COVID-19, […]

Sars cov 2 drives jak1 2 dependent local complement hyperactivation

Posted on | Posted on John Murphy | Leave a Comment on Sars cov 2 drives jak1 2 dependent local complement hyperactivation

Authors: Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, the best-characterized entry receptor for the disease-causing virus SARS-CoV-2, is highly expressed in the aforementioned tissues. However, the pathways that underlie the disease are still poorly understood. Here, […]