John Murphy, CEO The COVID-19 Long-haul Foundation Abstract The COVID-19 pandemic has revealed an extensive rheumatologic phenotype extending well beyond the respiratory tract. SARS-CoV-2 infection may be followed by arthralgia, […]
Long COVID and Vascular Injury in 2026: Emerging Evidence for Endothelial Dysfunction, Microvascular Disease, and Persistent Immunothrombotic Pathology
John Murphy, M.D., M.P.H., D.P.H. President COVID-19 Long-haul Foundation Abstract Long COVID, also termed post-COVID condition or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as one of the most […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Severe cerebral amyloid angiopathy related inflammation (CAA-ri) associated with vaccination
Michael Tang 1, Jane Kim 2, Kui Kai Lau 3, Koon Ho Chan 3, PMID: 39094435, DOI: 10.1016/j.jneuroim.2024.578406 Abstract Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rapid but reversible autoimmune encephalopathy where spontaneous autoantibody reaction against amyloid beta deposited […]
Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation–a controlled study
Roald Omdal, Ole Bernt Lenning, Grete Jonsson, Scientific Reports , Article number: (2026) Cite this article We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript […]
Scientists uncover biological cause of Long COVID brain fog in major breakthrough
By Theo Farrant New research offers what scientists describe as the first biological evidence of Long COVID brain fog. Scientists in Japan have identified a potential biological cause of Long COVID brain fog, […]
Research highlighting chronic inflammation opens path to treating illness that affects millions of Americans
A new study from investigators at Harvard and Beth Israel Deaconess Medical Center sheds light on why some people never fully recover from COVID-19. In research that analyzed blood samples […]
Chronic Inflammation Pathways Identified in Long COVID
I. Persistent Cytokine-Driven Inflammatory Signaling I.A. IL-6–Centered Inflammatory Axis Interleukin-6 (IL-6) has emerged as one of the most consistently elevated cytokines in Long COVID cohorts, serving as a central node […]
Inflammatory Markers as Predictors of Onset and Recovery of Olfactory and Gustatory Dysfunction in COVID-19 Patients
Burak Celik • Fatih Gul • Hacı Huseyin Dere, DOI: 10.7759/cureus.96003 Abstract Background Olfactory and gustatory dysfunctions are widely recognized as characteristic manifestations of COVID-19. However, the relationship between disease severity, inflammatory markers, and the […]
Inflammation: The Molecular Convergence of Gout, COVID-19, and Uric Acid Metabolism
Inflammation is not merely a symptom—it is a biological imperative. It orchestrates the body’s defense against infection, injury, and metabolic imbalance. Yet when dysregulated, inflammation becomes a crucible for chronic […]