Trained Innate Immunity, Epigenetics, and Covid-19


Authors: Alberto Mantovani, M.D., and Mihai G. Netea, M.D. Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in tissue repair and resistance against pathogens.1 Exposure to selected vaccines, such as bacille Calmette–Guérin (BCG) or microbial components, can increase the baseline tone of innate immunity and trigger […]

COVID-19 Science Update released: June 4, 2021 Edition 92


Authors: From the Office of the Chief Medical Officer, CDC COVID-19 Response, and the CDC Library, Atlanta GA. Intended for use by public health professionals responding to the COVID-19 pandemic. PEER-REVIEWED Safety, immunogenicity, and efficacy of the BNT162b2 COVID-19 vaccine in adolescents.external icon Frenck et al. NEJM (May 27, 2021). Key findings: Vaccine efficacy was 100% (95% CI 75.3%-100%) […]

The most vaccine-hesitant group of all? PhDs


A new study found that the most educated are the least likely to get jabbed Authors: RAY HALL The percentage of each education group that is somewhat vaccine hesitant. Source: Carnegie Mellon University There has been much debate over how to get the unvaccinated to get their jabs — shame them, bribe them persuade them, or treat them as victims […]

Interim Guidance for Antigen Testing for SARS-CoV-2


Authors: CDC Summary of Recent Changes Updates as of May 13, 2021 Updated guidance based on new published studies on antigen test performance. Clarification about which NAATs should be used for confirmatory testing. Considerations for people who have had previous SARS-CoV-2 infections and those who have been fully vaccinated. Two new antigen testing algorithms, one […]

Scientists explain possible causes of anaphylaxis following mRNA COVID-19 vaccination


Authors: By Angela Betsaida B. Laguipo, BSN In an effort to stem the spread of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen, vaccination efforts have been implemented in most countries. Two of the vaccines developed to prevent SARS-CoV-2 infection are the novel messenger ribonucleic acid (mRNA) […]

Anaphylaxis is a rare reaction in COVID-19 vaccination


Authors: R G Bellomo 1, C E Gallenga 2, Al Caraffa 3, G Tetè 4, G Ronconi 5, P Conti 6 Abstract Anaphylaxis is a severe multisystem reaction that occurs rapidly after the introduction of an antigen that would otherwise be a harmless substance. It is characterized by airway and respiratory problems, cardiovascular collapse, mucosal inflammation, and other complications, all severe symptoms that can cause death. […]

Interim Considerations: Preparing for the Potential Management of Anaphylaxis after COVID-19 Vaccination


Authors: CDC Summary of recent changes (last updated March 3, 2021) Considerations broadened to include use of Janssen (Johnson & Johnson) COVID-19 vaccine. Key Points Under the Emergency Use Authorizationsexternal icon for COVID-19 vaccines, appropriate medical treatment for severe allergic reactions must be immediately available in the event that an acute anaphylactic reaction occurs following administration of […]

FDA Authorizes Covid Booster Shots For Immunocompromised Patients


Authors: BY TYLER DURDEN After growing chatter over the past week, late on Thursday the U.S. Food and Drug Administration authorized booster shots for certain people with weakened immune systems, likely the launch of broader efforts to better protect against evasive variants like Delta. The agency said that other fully vaccinated individuals do not need […]

Deadly Lambda variant could be vaccine-resistant, new study says


Authors: By Hannah Sparks As the US struggles to suppress the rapidly advancing coronavirus Delta variant, new evidence has emerged that the latest Lambda mutation — ravaging parts of South America — won’t be slowed by vaccines. In a July 28 report appearing on bioRxiv, where the study awaits peer review prior to getting published, researchers in […]

Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen


Authors: Fatemeh Heidary 1, Reza Gharebaghi 2 3 Abstract Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies […]