Category: Autoimmune Disease

Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients

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Authors: Joanna Hellmuth 1 2, T Allen Barnett 3, Breton M Asken 4, J Daniel Kelly 5, Leonel Torres 6, Melanie L Stephens 4 7, Bryan Greenhouse 6, Jeffrey N Martin 5, Felicia C Chow 7 8, Steven G Deeks 9, Meredith Greene 10, Bruce L Miller 4 7, Wesley Annan 4 7, Timothy J Henrich 6, Michael J Peluso 9 As cases of coronavirus disease 2019 (COVID-19) mount worldwide, attention is needed on potential long-term neurologic impacts for the majority of patients who experience mild to moderate illness […]

COVID-19 Vaccination in Autoimmune Diseases: Patient Perspectives and Concerns

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Authors: Meghna Rao The Centers for Disease Control and Prevention (CDC) recommends that individuals with autoimmune diseases and those with weakened immune systems receive the COVID-19 vaccines; however, no solid data are currently available regarding their safety specifically in populations with autoimmune conditions.1 On the other hand, researchers have indicated that patients with autoimmune and inflammatory […]

Extrapulmonary manifestations of COVID-19

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Authors: Aakriti Gupta, Mahesh V. Madhavan, […]Donald W. Landry Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. […]

Complications Coronavirus Can Cause

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Authors: WebMD If you have COVID-19, the illness that comes from infection with the recently discovered coronavirus, your symptoms may be relatively mild and manageable at home. That’s true for most people. But if you’re older or have another illness such as diabetes or heart disease, you’re more at risk for the serious form of COVID-19. Some people — about 1 […]

Interferons (Alfa, Beta)

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Authors: NIH Interferons are a family of cytokines with antiviral properties. They have been suggested as a potential treatment for COVID-19 because of their in vitro and in vivo antiviral properties. Recommendation The COVID-19 Treatment Guidelines Panel recommends against the use of interferons for the treatment of patients with severe or critical COVID-19, except in a clinical trial (AIII). There is insufficient evidence to […]

Cytokine Storm

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Authors: David C. Fajgenbaum, M.D., and Carl H. June, M.D. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reminded us of the critical role of an effective host immune response and the devastating effect of immune dysregulation. This year marks 10 years since the first description of a cytokine storm that developed after chimeric […]

Can COVID-19 Immunity Last for Years?

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Author: Christina Aungst, PharmD Key takeaways: People who were sick with COVID-19 and recovered might have long-term immunity that lasts for months or years. We don’t know how long vaccine immunity lasts yet, but it is much safer to gain immunity from the vaccine than from getting COVID-19. Experts believe the vaccine will still work […]

SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy

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Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak significantly delaying the hope for the virus’ complete eradication. In the absence of effective vaccines, we need effective treatments with low adverse effects that can treat hospitalized patients with COVID-19 disease. In this study, we determined the existence of SARS-CoV-2-specific T cells within CD45RA– memory T […]

What is the role of T cells in COVID-19 infection? Why immunity is about more than antibodies

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Summary CD4+ T cells help B cells to produce antibodies and help CD8+ T cells to kill virus-infected cells One of the dominant cytokines produced by T cells is interferon gamma, a key player in controlling viral infection – see also [41] Lymphopenia is a main feature of COVID-19 infection, affecting CD4+ T cells, CD8+ […]

T cell responses in patients with COVID-19

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The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting to enable some general concepts to emerge. For More Information: https://www.nature.com/articles/s41577-020-0402-6