Pain in Long-Haul Illnesses: A Comprehensive Clinical and Molecular Review

January 28, 2026 | John Murphy | Leave a Comment

Pain in Long-Haul Illnesses: A Comprehensive Clinical and Molecular Review

🧠 Abstract Pain in long-haul illnesses—particularly post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID—represents a complex, multifactorial syndrome that transcends traditional diagnostic boundaries. This article synthesizes current evidence from…[...]

January 27, 2026 | John Murphy | Leave a Comment

Muscle Wasting in Long COVID: Etiology, Genomics, Physiology, Clinical Evaluation, and Prognosis

John Murphy, CEO The COVID-19 Long-haul Foundation Abstract Muscle wasting in long COVID represents a profound and underrecognized consequence of SARS‑CoV‑2 infection, affecting skeletal integrity and systemic resilience. This article…[...]

July 20, 2025 | John Murphy | Leave a Comment

Long COVID: A living systematic review

BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-081318, Cite this as: BMJ 2024;387:e081318 Abstract Objective To compare the effectiveness of interventions for the management of long covid (post-covid condition). Design Living systematic review. Data sources Medline, Embase, CINAHL, PsycInfo, Allied and Complementary…[...]

July 4, 2025 | John Murphy | Leave a Comment

Brain changes discovered in patients still dealing with long COVID

StudyFinds CHICAGO — There are distinct changes in the brains of individuals with long COVID, differing from those who have fully recovered from the virus, a new study reveals. Approximately one…[...]

May 3, 2025 | John Murphy | Leave a Comment

Long COVID: damaged mitochondria in muscles might be linked to some of the symptoms

Caroline Dalton, Associate Professor of Neuroscience and Genetics, Sheffield Hallam University It’s estimated around 3% of people in the UK experience long COVID – persistent, long-lasting symptoms after a COVID-19 infection. Long…[...]

March 9, 2025 | John Murphy | Leave a Comment

Navigating the Diagnostic Maze: A Case of Post-COVID-19 Tenosynovitis

Kasture Puspalingam • Malarkodi Suppamutharwyam, Navigating the Diagnostic Maze: A Case of Post-COVID-19 Tenosynovitis. Cureus 16(11): e73849. doi:10.7759/cureus.73849 Abstract Post-COVID-19 sequelae can include various complications, including musculoskeletal manifestations. Unvaccinated against COVID-19, a…[...]

February 14, 2025 | John Murphy | Leave a Comment

Lower back pain could affect up to a quarter of COVID-19 survivors

by: Linda Geddes Clinics should prepare for an increase in people seeking treatment for lower back pain in the aftermath of COVID-19 infection, researchers warn. Up to a quarter of…[...]

February 3, 2025 | John Murphy | Leave a Comment

A discovery in the muscles of long COVID patients may explain exercise troubles

By Will Stone, NPR Hit the gym. Get back in shape. That's what many patients with long COVID are told when they talk of the crushing fatigue that envelops them after…[...]

January 11, 2025 | John Murphy | Leave a Comment

Musculoskeletal Manifestations of COVID-19: Currently Described Clinical Symptoms and Multimodality Imaging Findings

Imran M. Omar , Jennifer S. Weaver, Jonathan D. Samet, et. al. https://doi.org/10.1148/rg.220036 Abstract COVID-19, the clinical syndrome produced by infection with SARS-CoV-2, can result in multisystem organ dysfunction, including respiratory failure and hypercoagulability,…[...]

December 26, 2024 | John Murphy | Leave a Comment

Pathophysiological, immunological, and inflammatory features of long COVID

Karen Bohmwald1,2†Benjamín Diethelm-Varela1†Linmar Rodríguez-Guilarte1, et. al. Front. Immunol., 27 February 2024, Volume 15 - 2024, https://doi.org/10.3389/fimmu.2024.1341600 The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality,…[...]