Persistent SARS-CoV-2 Spike Protein: Genomic Modulation, Immune Dysregulation, and Impaired Antibody Maturation

Author: John Murphy, CEO COVID 19 Long-haul Foundation Abstract The SARS-CoV-2 spike glycoprotein, central to viral entry and the target of mRNA vaccine platforms, has emerged as a persistent antigen…[...]

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Endothelial Dysfunction and Spike Protein Persistence in Long COVID: Mechanisms, Vulnerabilities, and Clinical Evidence

Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms affecting multiple organ systems. Among its most compelling…[...]

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Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID

Andrea Polli, Lode Godderis, Dries S. Martens, et. al., , BMC Medicine volume 23, Article number: 60 (2025) Cite this article Abstract Background Long-COVID is defined as the persistency or development of new symptoms 3 months after the initial SARS-CoV-2…[...]

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mRNA Vaccination and Arthritis: Etiological Mechanisms, Genomic Susceptibility, Diagnostic Pathways, and Therapeutic Outlook

John Murphy, President The COVID-19 Long-haul Foundation Abstract Messenger RNA (mRNA) vaccines have transformed infectious disease prevention, particularly during the COVID-19 pandemic. While their safety profile is robust, emerging evidence…[...]

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COVID-19 and immune dysregulation: Genomic pathways, clinical manifestations, and therapeutic strategies

John Murphy, CEO & President, COVID-19 Long-haul Foundation Abstract SARS-CoV-2 provokes a uniquely heterogeneous and dynamic immune response that ranges from efficient viral control to fulminant hyperinflammation and prolonged immune…[...]

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