Category: Autoimmune Disease

Pathological sequelae of long-haul COVID

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Saurabh Mehandru & Miriam Merad, Nature Immunology volume 23, pages194–202 ( Abstract The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and often debilitating sequelae are increasingly recognized in convalescent individuals, named ‘post-COVID-19 syndrome’ or ‘long-haul COVID’. Clinical symptomatology includes fatigue, malaise, dyspnea, defects […]

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

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Rik G. H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, et. al.Nature (2024) Abstract The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, […]

Ileocecal Intussusception in the Era of Coronavirus Disease 2019 (COVID-19) Infection and Multisystem Inflammatory Syndrome in Children (MIS-C): A Case Report and Literature Review

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Niharika Alla • Thaer Abdul-Hadi • Florentina Litra: June 19, 2024, DOI: 10.7759/cureus.62731  Abstract Ileocecal intussusception (ICI) is the most common abdominal emergency and cause of intestinal obstruction in young children, carrying a high risk of mortality and morbidity. Enteric viral infectious and inflammatory syndromes are known triggers for intussusception (ileoileal and ileocolic) by causing mesenteric lymphoid hyperplasia that may act as […]

China’s CDC Reports New COVID-19 Cases Hit Nearly 20 Percent

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Authored by Alex Wu via The Epoch Times, The Chinese Center for Disease Control and Prevention (CDC) reported that new COVID-19 infections in the country of origin have increased to nearly 20 percent in the past few weeks, as two new Omicron subvariants spread across the country. But while increases to China’s official COVID-19 test […]

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

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Roxana Gheorghita1,2Iuliana Soldanescu3Andrei Lobiuc2 , et. al., Front. Immunol., 03 March 2024, Sec. Viral Immunology, Volume 15 – 2024 | https://doi.org/10.3389/fimmu.2024.1344086 The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with the virus, a significant […]

Pathophysiological, immunological, and inflammatory features of long COVID

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Karen Bohmwald1,2†Benjamín Diethelm-Varela1†Linmar Rodríguez-Guilarte1 , et. al., Front. Immunol., 27 February 2024, Sec. Viral Immunology, Volume 15 – 2024 | https://doi.org/10.3389/fimmu.2024.1341600 The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing substantial social and economic burdens on nations. While most of the attention and therapeutic efforts have […]

First-Of-Its-Kind Study Explains Why Some People Don’t Get COVID-19

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JUN 20, 2024 – Authored by Marina Zhang via The Epoch Times  Researchers have discovered why some people remain uninfected by the COVID-19 virus—even after their nasal cavities are exposed to it. According to a recent study, these people have faster and more subtle immune responses than those who develop symptomatic COVID-19. “These findings shed […]

Complement system causes cell damage in long Covid

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January, 2024, Source: University of Zurich Science Daily Summary: Long Covid patients suffer from chronic symptoms such as fatigue or shortness of breath. As researchers have discovered, this is to some extent due to a part of our immune system called the complement system. The study identified a pattern in the blood proteins that will […]

Prior COVID-19 Infection May Protect Against Common Colds: Study

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SATURDAY, JUN 15, 2024 –Authored by Zachary Stieber via The Epoch Times  People with a history of COVID-19 infection are better protected against common colds than people who received a COVID-19 vaccine, according to a new study. Infection and vaccination triggered similar antibody responses in study participants, but T cell responses targeting endemic coronaviruses, which […]

Long Covid Defined

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Authors: E. Wesley Ely, M.D., M.P.H. https://orcid.org/0000-0003-3957-2172, Lisa M. Brown, M.P.H., and Harvey V. Fineberg, M.D., Ph.D., for the National Academies of Sciences, Engineering, and Medicine Committee on Examining the Working Definition for Long Covid, DOI: 10.1056/NEJMsb2408466 The Covid-19 pandemic has been perceived mainly as a dangerous acute outbreak of infection that killed more than a million people in the United States and 7 million worldwide.1,2 However, […]