Covid-19: Two rare vaccine side effects detected in large global study


BMJ 2024; 384 doi: https://doi.org/10.1136/ bmj.q488 (2024) The largest vaccine safety study to date has identified two new, but very rare, side effects associated with covid-19 vaccines—transverse myelitis and acute disseminated encephalomyelitis. The Global Vaccine Data Network cohort study included 99 million vaccinated people from 10 sites across eight countries. Researchers compared the observed with expected rate for 13 neurological, […]

SARS-COV-2 a trigger of myelin oligodendrocyte glycoprotein-associated disorder


Authors: Magnus Johnsson,Fredrik Asztely, et. al. June 2022 Annals of Clinical and Translational Neurology Abstract SARS-COV-2 frequently cause neurological disorders and is sometimes associated with onset of autoimmune diseases affecting the nervous system. Over recent years, a rare but distinct diagnosis designated myelin oligodendrocyte glycoprotein-associated disorder (MOGAD) has been recognized in patients with attacks of […]

Pathophysiology, diagnosis, and management of neuroinflammation in covid-19


BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2022-073923 (Published 18 August 2023)Cite this as: BMJ 2023;382:e073923, Rachel L Brown123,  Laura Benjamin24,  Michael P Lunn12,  Tehmina Bharucha25,  Michael S Zandi12,  Chandrashekar Hoskote6,  Patricia McNamara2,  Hadi Manji1 Abstract Although neurological complications of SARS-CoV-2 infection are relatively rare, their potential long term morbidity and mortality have a significant impact, given the large numbers of infected patients. Covid-19 is […]

Study in Mice Suggests that COVID-19 Increases Risk of Developing Parkinson’s Disease


Thomas Jefferson University May 18, 2022 New research finds that the novel coronavirus can make the mouse brain more susceptible to a toxin that induces nerve-cell loss seen in Parkinson’s. PHILADELPHIA – Brain fog, headaches, insomnia are some of the neurological symptoms doctors have observed in COVID-19 patients. Neurological sequelae after a viral infection is not […]

Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain


Héctor Hernández-Parra1,2 Octavio Daniel Reyes-Hernández3 Gabriela Figueroa-González4 Manuel González-Del Carmen5 Maykel González-Torres6 Sheila I. Peña-Corona2 Benjamín Florán7 Hernán Cortés8* Gerardo Leyva-Gómez2* https://pubmed.ncbi.nlm.nih.gov/36998270/ Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System […]

Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome


Published online 2021 Dec 24. doi: 10.3390/medicina58010028 PMCID: PMC8778312 PMID: 350563 C. (Linda) M. C. van Campen,1,* Peter C. Rowe,2 and Frans C. Visser1 Olli J. Polo, Academic Editor Abstract Background and Objectives: Symptoms and hemodynamic findings during orthostatic stress have been reported in both long-haul COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but little work has directly compared patients from these two […]

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside


npj Parkinson’s Disease volume 6, Article number: 18 (2020) Cite this article Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central […]

A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination againstCOVID-19


Authors: Michael Mörz Abstract: The current report presents the case of a 76-year-old man with Parkinson’s disease (PD)who died three weeks after receiving his third COVID-19 vaccination. The patient was first vac-cinated in May 2021 with the ChAdOx1 nCov-19 vector vaccine, followed by two doses of theBNT162b2 mRNA vaccine in July and December 2021. The […]

New research provides insight into Long COVID and ME


Authors: University of Otago July 12, 2022: Science Daily Summary: Researchers have uncovered how post-viral fatigue syndromes, including Long COVID, become life-changing diseases and why patients suffer frequent relapses. Arising commonly from a viral infection, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), is known to cause brain-centred symptoms of neuroinflammation, loss of homeostasis, brain fog, lack of […]

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms


Authors: Amy D. Proal1 and Michael B. VanElzakker1,2* The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients who sustain an acute SARS-CoV-2 infection are developing a wide range of persistent symptoms that do not resolve over the course of many […]