John Murphy, CEO The COVID-19 Long haul Foundation Abstract Post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID, encompass a heterogeneous constellation of neurological, autonomic, cardiovascular, respiratory, gastrointestinal, musculoskeletal […]
Neurological Long COVID
John Murphy, CEO, The COVID-19 Long haul Foundation A mechanistic synthesis of post-acute neurological sequelae of SARS-CoV-2 infection Abstract Neurological manifestations constitute one of the most consequential and biologically heterogeneous […]
Long COVID as a Spectrum of Distinct Biological Phenotypes
A mechanistic synthesis of the emerging phenotype-based model of post-acute sequelae of SARS-CoV-2 infection John Murphy, CEO The COVID-19 Long haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 […]
Long COVID and Peripheral Neuropathy: Clinical Phenotypes, Pathobiology, Diagnosis, and Treatment
John Murphy, CEO, The Covid-19 Long Haul Foundation A Narrative Review Abstract Importance: Peripheral nervous system dysfunction is increasingly recognized among the neurological manifestations of Long COVID. Small-fiber neuropathy (SFN), […]
COVID-19 and the Motor–Sensory Brain: Pathobiology, Microvascular Injury, Neurophysiology, Clinical Manifestations, Therapeutic Strategies, and Long-Term Outcomes
John Murphy, CEO COVID-19 Long-haul Founndation Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), initially characterized as a respiratory pathogen, is now recognized as a systemic vascular and neurotropic disease […]
NIH RECOVER Clinical Trials and the First Emergence of Interventional Results in Long COVID Research: A Translational Turning Point
A Scholarly Review for Scientific American (Submission-Style Manuscript) John Murphy, M.D., M.P.H., D.P.H., President, COVID-19 Long-Haul Foundation Abstract The NIH RECOVER Initiative represents the largest coordinated research program investigating post–acute […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
COVID-19–Associated Neuropathy of the Feet and Legs: Etiology, Pathophysiology, Clinical Course, and Therapeutic Approaches
Abstract Peripheral neuropathy involving the feet and legs has emerged as one of the most prevalent and disabling neurological sequelae associated with acute and post-acute COVID-19 illness. Although initially overshadowed […]
Vertigo as a Sequela of COVID‑19 Infection
John Murphy, CEO, The COVID-19Long-haul Foundation I. Etiology (Deep Expansion) Vertigo following COVID‑19 infection is not a monolithic entity but rather the product of several converging pathogenic mechanisms. The etiology […]
Peripheral Nerve Neuropathy in Post‑Acute Sequelae of SARS‑CoV‑2 Infection (PASC)
John Murphy, M.D., M.P.H., D.P.H. Covid-19LOng-haul Foundation Abstract Post‑acute sequelae of SARS‑CoV‑2 infection (PASC), commonly known as long‑COVID, is a multisystem disorder affecting 10–20% of patients following acute infection. Among […]