John Murphy, CEO, The COVID-19 Long Haul Foundation Abstract SARS-CoV-2 infection has been associated with delayed nail abnormalities including Beau’s lines, onychomadesis, transverse leukonychia, and chromonychia (“COVID nails”). These manifestations […]
Long COVID–Associated Memory Impairment: Neurovascular, Immunologic, and Molecular Mechanisms with Translational Implications
John Murphy, CEO The COVIC-19 Long Faoundation Abstract Persistent cognitive impairment, particularly memory dysfunction, is among the most prevalent and disabling manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC), commonly […]
Chronic Inflammation Pathways Identified in Long COVID
I. Persistent Cytokine-Driven Inflammatory Signaling I.A. IL-6–Centered Inflammatory Axis Interleukin-6 (IL-6) has emerged as one of the most consistently elevated cytokines in Long COVID cohorts, serving as a central node […]
Energy depletion in long-COVID: etiology, physiology, pathology, and clinical findings of exhaustion
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract Persistent, debilitating fatigue and exertional intolerance are among the most frequent and disabling features of post-acute sequelae of SARS-CoV-2 infection […]
COVID-19 and Cataractogenesis: Mechanistic Insights into Viral-Induced Ocular Pathology
Abstract Cataracts, the leading cause of blindness worldwide, are traditionally associated with aging, oxidative stress, and metabolic disorders. However, emerging evidence suggests that SARS-CoV-2 infection may accelerate or precipitate cataract […]
Persistent Shadows: Depression, Long COVID, and the Future of Mental Health Care
Author: John Murphy Affiliation: COVID-19 Long-haul Foundation Abstract Long COVID has emerged as a multifaceted syndrome with profound neuropsychiatric consequences. Among its most persistent and disabling sequelae is depression, which […]
Endothelial Disruption in Long COVID: Unraveling the Vascular Legacy of SARS-CoV-2
John Murphy, The COVID 19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a chronic multisystem disorder affecting millions worldwide. Among its most […]
COVID-19 coagulopathy, thrombosis, and bleeding
Noel C. Chan, Jeffrey I. Weitz, Blood (2020) 136 (4): 381–383.https://doi.org/10.1182/blood.2020007335 In this issue of Blood, Al-Samkari et al expand our understanding of thrombosis and bleeding risks and their predictors in hospitalized patients with […]
Hyperglycemia in Severe and Critical COVID-19 Patients: Risk Factors and Outcomes
Viet Tran Le • Quoc Hung Ha • Minh Triet Tran • Ngoc Trong Le • et. al., DOI: 10.7759/cureus.27611 Abstract Background: Hyperglycemia is commonly seen in critically ill patients. This disorder was also seen in coronavirus disease 2019 […]
Sudden Sleep Collapse: A Long-COVID Nightmare
Long COVID can trigger sudden collapses in consciousness or overwhelming sleepiness through a mix of neurological, immunological, and autonomic dysfunctions. Here’s how the body gets hijacked into shutdown mode: 🧠 […]