Author: John Murphy, CEO, The COVID-19 Long Haul Foundation Abstract Background Transverse myelitis (TM) is an uncommon inflammatory disorder of the spinal cord characterized by acute or subacute neurological dysfunction […]
The Molecular Genomics of SARS-CoV-2: An Integrated Multi-Omics Perspective on Viral Evolution, Genome Organization, Replication, Host Interaction, and Systems Biology
John Murphy, CEO The COVID19 Long-haul Foundation Abstract The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) fundamentally transformed modern virology, molecular genetics, systems biology, structural biology, immunology, and […]
Nail Manifestations of SARS-CoV-2 Infection (COVID-19): Etiology, Pathophysiology, Histopathology, Clinical Features, and Outcomes
John Murphy, CEO, The COVID-19 Long Haul Foundation Abstract SARS-CoV-2 infection has been associated with delayed nail abnormalities including Beau’s lines, onychomadesis, transverse leukonychia, and chromonychia (“COVID nails”). These manifestations […]
Long COVID–Associated Memory Impairment: Neurovascular, Immunologic, and Molecular Mechanisms with Translational Implications
John Murphy, CEO The COVIC-19 Long Faoundation Abstract Persistent cognitive impairment, particularly memory dysfunction, is among the most prevalent and disabling manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC), commonly […]
Chronic Inflammation Pathways Identified in Long COVID
I. Persistent Cytokine-Driven Inflammatory Signaling I.A. IL-6–Centered Inflammatory Axis Interleukin-6 (IL-6) has emerged as one of the most consistently elevated cytokines in Long COVID cohorts, serving as a central node […]
Energy depletion in long-COVID: etiology, physiology, pathology, and clinical findings of exhaustion
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract Persistent, debilitating fatigue and exertional intolerance are among the most frequent and disabling features of post-acute sequelae of SARS-CoV-2 infection […]
COVID-19 and Cataractogenesis: Mechanistic Insights into Viral-Induced Ocular Pathology
Abstract Cataracts, the leading cause of blindness worldwide, are traditionally associated with aging, oxidative stress, and metabolic disorders. However, emerging evidence suggests that SARS-CoV-2 infection may accelerate or precipitate cataract […]
Persistent Shadows: Depression, Long COVID, and the Future of Mental Health Care
Author: John Murphy Affiliation: COVID-19 Long-haul Foundation Abstract Long COVID has emerged as a multifaceted syndrome with profound neuropsychiatric consequences. Among its most persistent and disabling sequelae is depression, which […]
Endothelial Disruption in Long COVID: Unraveling the Vascular Legacy of SARS-CoV-2
John Murphy, The COVID 19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a chronic multisystem disorder affecting millions worldwide. Among its most […]
COVID-19 coagulopathy, thrombosis, and bleeding
Noel C. Chan, Jeffrey I. Weitz, Blood (2020) 136 (4): 381–383.https://doi.org/10.1182/blood.2020007335 In this issue of Blood, Al-Samkari et al expand our understanding of thrombosis and bleeding risks and their predictors in hospitalized patients with […]