Category: P-selectin

The coagulopathy, endotheliopathy, and vasculitis of COVID-19

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Authors: Toshiaki Iba 1, Jean Marie Connors 2, Jerrold H Levy 3 PMID: 32918567 PMCID: PMC7486586 DOI: 10.1007/s00011-020-01401-6 Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the elevated D-dimer without remarkable changes of other global coagulation markers is associated with various thrombotic complications and disease severity. The purpose of this review is to elucidate the pathophysiology of this unique coagulopathy. Methods The authors performed […]

COVID-19-associated coagulopathy: An exploration of mechanisms

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Authors: Meaghan E Colling 1, Yogendra Kanthi 2 PMID: 32558620 PMCID: PMC7306998 OI: 10.1177/1358863X20932640 Abstract An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to the virus SARS-CoV-2, has infected millions of people and remains a threat to many more. Most critically ill patients have respiratory failure and there is an international effort to understand mechanisms and predictors of […]

Role of von Willebrand Factor in COVID-19 Associated Coagulopathy

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Authors: Zhen W Mei, Xander M R van Wijk, Huy P Pham, Maximo J Marin The Journal of Applied Laboratory Medicine, Volume 6, Issue 5, September 2021, Pages 1305–1315,  https://doi.org/10.1093/jalm/jfab042Published: 13 June 2021 Abstract Background COVID-19, the disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can present with symptoms ranging from none to severe. Thrombotic events occur […]

Elevated P-Selectin in Severe Covid-19: Considerations for Therapeutic Options

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Authors: Chiara Agrati,1Veronica Bordoni,1Alessandra Sacchi,1Nicola Petrosillo,1Emanuele Nicastri,1Franca Del Nonno,1Gianpiero D’Offizi,1Fabrizio Palmieri,1Luisa Marchioni,1Maria Rosaria Capobianchi,1Andrea Antinori,1Giuseppe Ippolito,1 and Michele Bibas1 Mediterr J Hematol Infect Dis. 2021; 13(1): e2021016.Published online 2021 Mar 1.  doi:  10.4084/MJHID.2021.016 Abstract Background Coronavirus disease 2019 (COVID-19) is mainly a respiratory tract disease and acute respiratory failure with diffuse microvascular pulmonary thrombosis are critical aspects of […]