Category: Coagulation

Mesenteric thrombosis in patients with coronavirus disease: comprehensive assessment and treatment

Posted on | Posted on John Murphy | Leave a Comment on Mesenteric thrombosis in patients with coronavirus disease: comprehensive assessment and treatment

Authors: A.R. Stasyshyn , .S. Stadnyk, A.I. Doroshak,I et. al., (Medical perspectives) 27(1):86-91 DOI:10.26641/2307-0404.2022.1.254332 Abstract Acute mesenteric circulatory disorder belongs to the most serious diseases of the abdominal cavity. Being an emer­gency condition, it is associated with high mortality. Coronavirus infection is an anthroponotic disease in the group of acute respiratory infections, is characterized by damage […]

Three-year outcomes of post-acute sequelae of COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Three-year outcomes of post-acute sequelae of COVID-19

Miao Cai, , Yan Xie, Eric J. Topol & Ziyad Al-Aly Nature Medicine volume 30, pages1564–1573 (2024) Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in many organ systems. Risks of these sequelae have been characterized up to 2 years after infection, but longer-term follow-up is limited. Here we built a cohort of 135,161 […]

Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment

Posted on | Posted on John Murphy | Leave a Comment on Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment

Authors: Patrick J Lindsay, a Rachel Rosovsky, b Edward A Bittner, c and Marvin G. Chang c ABSTRACT Introduction COVID-19-associated coagulopathy (CAC) is a well-recognized hematologic complication among patients with severe COVID-19 disease, where macro- and micro-thrombosis can lead to multiorgan injury and failure. Major societal guidelines that have published on the management of CAC are based on consensus of expert opinion, with […]

Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series

Posted on | Posted on John Murphy | Leave a Comment on Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series

Ali Tabatabai 1, Joseph Rabin 2, Jay Menaker 2, Ronson Madathil 3, Samuel Galvagno 4, Ashley Menne 5, Jonathan H Chow 4, Alison Grazioli 6, Daniel Herr 1, Kenichi Tanaka 4, Thomas Scalea 2, Michael Mazzeffi 4Affiliations expand PMID: 32539272 PMCID: PMC7242090 DOI: 10.1213/XAA.0000000000001236 Abstract Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated […]

Whole genome sequencing reveals host factors underlying critical Covid-19

Posted on | Posted on John Murphy | Leave a Comment on Whole genome sequencing reveals host factors underlying critical Covid-19

Authors: Athanasios Kousathanas, Erola Pairo-Castineira, J. Kenneth BaillieArticle Published: 07 March 2022 nature  articles  article We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply. Abstract Critical Covid-19 is […]

Role of von Willebrand Factor in COVID-19 Associated Coagulopathy

Posted on | Posted on John Murphy | Leave a Comment on Role of von Willebrand Factor in COVID-19 Associated Coagulopathy

Authors: Zhen W Mei, Xander M R van Wijk, Huy P Pham, Maximo J Marin The Journal of Applied Laboratory Medicine, Volume 6, Issue 5, September 2021, Pages 1305–1315,  https://doi.org/10.1093/jalm/jfab042Published: 13 June 2021 Abstract Background COVID-19, the disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can present with symptoms ranging from none to severe. Thrombotic events occur […]

Post-acute COVID-19 syndrome

Posted on | Posted on John Murphy | Leave a Comment on Post-acute COVID-19 syndrome

Authors: Ani Nalbandian, Kartik Sehgal, Elaine Y. Wan Nature Medicine volume 27, pages601–615 (2021) Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of […]

Better Anticoagulated Than Not! Hypercoagulability in COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Better Anticoagulated Than Not! Hypercoagulability in COVID-19

Authors: Dhauna P. Karam, MD1 Incidence of thrombotic complications in patients with COVID-19 who are critically ill is high, with an estimated incidence of 31% for arterial or venous thromboembolism (VTE), acute pulmonary embolism, ischemic stroke, and myocardial infarction. On the basis of the study by Klok et al,1 pulmonary embolism was the most common thrombotic […]

COVID-19 – A vascular disease

Posted on | Posted on John Murphy | Leave a Comment on COVID-19 – A vascular disease

Authors: Hasan K. Siddiqi,a,bPeter Libby,a,⁎ and Paul M Ridkera,b Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to multi-system dysfunction with emerging evidence suggesting that SARS-CoV-2-mediated endothelial injury is an important effector of the virus. Potential therapies that address vascular system dysfunction and its sequelae may have an important role in treating SARS-CoV-2 infection and its […]

Peer-Reviewed Publications about COVID-19 (Coronavirus) by Yale Authors

Posted on | Posted on John Murphy | Leave a Comment on Peer-Reviewed Publications about COVID-19 (Coronavirus) by Yale Authors

Sharing knowledge about COVID-19 (coronavirus) is vital to our efforts as we fight the pandemic. Yale researchers are publishing their discoveries about COVID-19 (coronavirus) in peer-reviewed publications. Check back frequently to access the latest findings. Peer-Reviewed COVID-19 Publications from Yale A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?Tuan […]