Category: coagulopathy

Spinal cord involvement in COVID-19: A review

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Ravindra Kumar Garg,1 Vimal Kumar Paliwal,2 and Ankit Gupta2 J Spinal Cord Med. 2023; 46(3): 390–404. Published online 2021 Mar 11. doi: 10.1080/10790268.2021.1888022 PMCID: PMC10114972PMID: 33705268 Abstract Context: Recent literature points towards myelitis, like encephalitis, as a common central nervous system complication of COVID-19. This review elaborates on disorders of the spinal cord caused by the SARS-CoV-2 virus. Objectives: To review the published data about […]

Extensive thrombosis after COVID-19 vaccine: cause or coincidence

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Authors: Luís Lourenço Graça ,1 Maria João Amaral ,2 Marco Serôdio,3 Beatriz Costa2 SUMMARYA 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1 day after administration of COVID-19 vaccine. Bloodwork revealed anaemia and thrombocytosis. Abdominal CT angiography showed a mural thrombus at the emergence of the coeliac trunk, hepatic and splenic arteries, […]

Intestinal Damage in COVID-19: SARS-CoV-2 Infection and Intestinal Thrombosis

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Authors: Xiaoming Wu1, Haijiao Jing1, Chengyue Wang1, Yufeng Wang1, Nan Zuo1, Tao Jiang2*, Valerie A. Novakovic3 and Jialan Shi1,3,4* Front. Microbiol., 22 March 2022 | https://doi.org/10.3389/fmicb.2022.860931 The intestinal tract, with high expression of angiotensin-converting enzyme 2 (ACE2), is a major site of extrapulmonary infection in COVID-19. During pulmonary infection, the virus enters the bloodstream forming viremia, which infects and damages extrapulmonary organs. Uncontrolled viral […]

Review of Mesenteric Ischemia in COVID-19 Patients

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Authors: Amit Gupta, Oshin Sharma, Kandhala Srikanth, Rahul Mishra, Amoli Tandon & Deepak Rajput  Indian Journal of Surgery (2022) Published: 11 March 2022 Abstract The new coronavirus (COVID-19) infection, first detected in Wuhan, China in 2019 has become a pandemic that has spread to nearly every country in the world. Through October 11, 2021, more than 23 billion confirmed cases and 4.8 million […]

Elevated clotting factor V levels linked to worse outcomes in severe COVID-19 infections

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Authors: Jonathan A. Stefely,Bianca B. Christensen,Tasos Gogakos,Jensyn K. Cone Sullivan … See all authors First published: 24 August 2020 https://doi.org/10.1002/ajh.25979 Abstract Coagulopathy causes morbidity and mortality in patients with coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Yet, the mechanisms are unclear and biomarkers are limited. Early in the pandemic, we observed markedly elevated […]

Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment

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Authors: Patrick J Lindsay, a Rachel Rosovsky, b Edward A Bittner, c and Marvin G. Chang c ABSTRACT Introduction COVID-19-associated coagulopathy (CAC) is a well-recognized hematologic complication among patients with severe COVID-19 disease, where macro- and micro-thrombosis can lead to multiorgan injury and failure. Major societal guidelines that have published on the management of CAC are based on consensus of expert opinion, with […]

Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series

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Ali Tabatabai 1, Joseph Rabin 2, Jay Menaker 2, Ronson Madathil 3, Samuel Galvagno 4, Ashley Menne 5, Jonathan H Chow 4, Alison Grazioli 6, Daniel Herr 1, Kenichi Tanaka 4, Thomas Scalea 2, Michael Mazzeffi 4Affiliations expand PMID: 32539272 PMCID: PMC7242090 DOI: 10.1213/XAA.0000000000001236 Abstract Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated […]

Whole genome sequencing reveals host factors underlying critical Covid-19

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Authors: Athanasios Kousathanas, Erola Pairo-Castineira, J. Kenneth BaillieArticle Published: 07 March 2022 nature  articles  article We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply. Abstract Critical Covid-19 is […]

Age- and Sex-Specific Incidence of Cerebral Venous Sinus Thrombosis Associated With Ad26.COV2.S COVID-19 Vaccination

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Authors: Aneel A. Ashrani, MD, MS1; Daniel J. Crusan, BS2; Tanya Petterson, MS2; et al JAMA Intern Med. 2022;182(1):80-83. doi:10.1001/jamainternmed.2021.6352 Recent reports1–4 suggest a possible association between Ad26.COV2.S (Johnson & Johnson/Janssen) COVID-19 vaccination and cerebral venous sinus thrombosis (CVST). Estimates of postvaccination CVST risk require accurate age- and sex-specific prepandemic CVST incidence rates; however, reported rates vary widely.5 We compared the age- and sex-specific CVST rates after […]

COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies

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Authors: Eleonora Calabretta, 1 , 12 Jose M. Moraleda, 2 Massimo Iacobelli, 3 Ruben Jara, 4 Israel Vlodavsky, 5 Peter O’Gorman, 6 Antonio Pagliuca, 7 Clifton Mo, 8 Rebecca M. Baron, 9 Alessio Aghemo, 10 , 12 Robert Soiffer, 8 Jawed Fareed, 11 Carmelo Carlo‐Stella, 1 , 12 , * and Paul Richardson 8 , * Br J Haematol. 2021 Apr; 193(1): 43–51.Published online 2021 Feb 4.  doi:  10.1111/bjh.17240 PMCID:  PMC8014053PMID: 33538335 Introduction The coronavirus disease 2019 (COVID‐19) pandemic, a viral illness caused by the severe acute respiratory syndrome coronavirus‐2 […]