The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches


Roxana Gheorghita1,2Iuliana Soldanescu3Andrei Lobiuc2 , et. al., Front. Immunol., 03 March 2024, Sec. Viral Immunology, Volume 15 – 2024 | https://doi.org/10.3389/fimmu.2024.1344086 The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with the virus, a significant […]

Evolution of neurologic symptoms in non-hospitalized COVID-19 “long haulers”


Authors: Sareen T. Ali,Anthony K. Kang,Tulsi R. Patel,Jeffrey R. Clark, et. al. ,May 2022 Annals of Clinical and Translational Neurology Abstract Objective We characterized the evolution of neurologic symptoms and self-perceived recovery of non-hospitalized COVID-19 “long haulers” 6–9 months after their initial Neuro-COVID-19 clinic evaluation. Methods In this follow-up study on the first 100 patients, 50 […]

Long COVID Comes Into the Light


We’re finally starting to see the truth about the vexing condition. It’s not what we thought. BY JEFF WISE; 2023 Slate Even before 2020’s first horrific wave of COVID-19 deaths subsided, reports surfaced warning of a brutal second punch: Instead of recovering quickly after a mild infection, some people were suffering from symptoms that lingered or […]

New research points to possible reason for long COVID


A Spanish study suggests that SARS-CoV-2 mediated vagus nerve dysfunction (VND) could be responsible for long COVID. By SHIRA SILKOFF, FEBRUARY 2022 – The Jerusalem Post Many symptoms of post-COVID syndrome could be caused by lasting damage sustained to one of the most important nerves in the human body during initial infection with coronavirus, new research has […]

Cognitive dysfunction in post-COVID-19 condition: Mechanisms, management, and rehabilitation


Marika Möller, Kristian Borg, Christer Janson, Maria Lerm, Johan Normark, Katarina NiwardSeptember 2023, Journal of Internal MedicineVolume 294, Issue 5 p. 563-581 Abstract The long-term effects of COVID-19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post-COVID-19 condition (PCC). Prolonged cognitive […]

Novel MRI reveals brain changes in long COVID patients


by Radiological Society of North America, NOVEMBER 22, 2023 People with long COVID exhibit patterns of changes in the brain that are different from fully recovered COVID-19 patients, according to research being presented next week at the annual meeting of the Radiological Society of North America (RSNA). “To the best of our knowledge, this is the first study […]

What is the long-term cognitive impact of COVID-19, and what are its predictors?


Dr. Sanchari Sinha Dutta, Ph.D. Jan 9 2023 Reviewed by Danielle Ellis, B.Sc. Medical Life Sciences Neuropsychology Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, has caused massive damage to the healthcare and economic sectors worldwide. Although the virus causes asymptomatic or mildly symptomatic infection in most affected individuals, long-term clinical […]

Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain


Héctor Hernández-Parra1,2 Octavio Daniel Reyes-Hernández3 Gabriela Figueroa-González4 Manuel González-Del Carmen5 Maykel González-Torres6 Sheila I. Peña-Corona2 Benjamín Florán7 Hernán Cortés8* Gerardo Leyva-Gómez2* https://pubmed.ncbi.nlm.nih.gov/36998270/ Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System […]

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside


David Sulzer, Angelo Antonini, Valentina Leta, Anna Nordvig, Richard J. Smeyne, James E. Goldman, Osama Al-Dalahmah, Luigi Zecca, Alessandro Sette, Luigi Bubacco, Olimpia Meucci, Elena Moro, Ashley S. Harms, Yaqian Xu, Stanley Fahn & K. Ray Chaudhuri  npj Parkinson’s Disease volume 6, Article number: 18 (2020) Cite this article Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus […]

Impact of Systemic Diseases on Olfactory Function in COVID-19 Infected Patients


Authors: Ayat A Awwad,1 Osama MM Abd Elhay,2 Moustafa M Rabie,3 Eman A Awad,4 Fatma M Kotb,4 Hend M Maghraby,4 Rmadan H Eldamarawy,4 Yahia MA Dawood,1 Mostafa IEI Balat,1 Ahmed IM Hasan,5 Ahmed H Elsheshiny,6 Said SMM El Sayed,2 Albayoumi AB Fouda,2 Ahmad MF Alkot2 DovPress November 7, 2022 1Otorhinolaryngology department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Medical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 3Public Health […]