Authors: By Suchandrima BhowmikAug 15 2021Reviewed by Benedette Cuffari, M.Sc. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus that causes coronavirus disease 2019 (COVID-19), is associated with high […]
Inflammatory brain injury higher in men with acute COVID-19, finds study
Download PDF Copy Authors: By Dr. Liji Thomas, MD The coronavirus disease 2019 (COVID-19) pandemic has been associated with both short- and long-term neurologic complications, including stroke, brain fog and persistent tiredness. […]
Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider
Authors: Aurélie Najm1, http://orcid.org/0000-0003-1105-5640Alessia Alunno2, Xavier Mariette3,4, http://orcid.org/0000-0001-6612-7336Benjamin Terrier5,6, http://orcid.org/0000-0003-2406-161XGabriele De Marco7,8, Jenny Emmel9, Laura Mason9, Dennis G McGonagle7,10 and http://orcid.org/0000-0002-8411-7972Pedro M Machado11,12,13 Abstract Background The SARS-CoV-2 pandemic is a global health problem. Beside the specific pathogenic effect of SARS-CoV-2, […]
Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality
Authors: Bandar Alosaimi1,2, Ayman Mubarak3, Maaweya E. Hamed3, Abdullah Z. Almutairi4, Ahmed A. Alrashed5, Abdullah AlJuryyan6, Mushira Enani7,Faris Q. Alenzi8 and Wael Alturaiki9* COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality. […]
COVID-19 is, in the end, an endothelial disease
Authors: Peter Libby, Thomas Lüscher The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that normally maintain homeostasis. This tightly […]
COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury
Authors: Roberto F. Nicosia,∗∗ Giovanni Ligresti,† Nunzia Caporarello,‡ Shreeram Akilesh,∗ and Domenico Ribatti§ Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular complications characterized by thrombosis of small, medium, and large vessels. […]
Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy
Authors: Jun Zhang 1, Kristen M Tecson 1, Peter A McCullough 1 2 3 Great attention has been paid to endothelial dysfunction (ED) in coronavirus disease 2019 (COVID-19). There is growing evidence to suggest that the angiotensin […]
What is cytokine release syndrome?
Authors: Medical News Today Cytokine release syndrome (CRS) can cause a variety of symptoms, including fever, headaches, and nausea. The symptoms can become severe quickly. CRS occurs when the immune system […]
What Is a Cytokine Storm? Doctors Explain How Some COVID-19 Patients’ Immune Systems Turn Deadly
Authors: Sarah Bradley The news cycle is heavily saturated with stress-inducing information about COVID-19, but one of the most worrying aspects so far has been the huge disparity in the way the novel […]
Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper
Authors: Sonu Bhaskar,1,2,3,* Akansha Sinha,1,4 Maciej Banach,1,5,6,7 Shikha Mittoo,1,8 Robert Weissert,1,9 Joseph S. Kass,1,10 Santhosh Rajagopal,1,11 Anupama R. Pai,1,12 and Shelby Kutty1,13,14 Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions […]