Immune damage in Long Covid

Links between the complement and coagulation systems could lead to Long Covid therapies WOLFRAM RUF Authors Info & Affiliations, SCIENCE, 18 Jan 2024, Vol 383, Issue 6680, pp. 262-263, DOI: 10.1126/science.adn1077, BY CARLO CERVIA-HASLER, SARAH C. BRÜNINGK, TOBIAS HOCH, ET AL. Acute infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause a respiratory illness that can be associated with systemic […]

Complement system causes cell damage in long Covid

Date: January 18, 2024 Source:University of Zurich Summary: Long Covid patients suffer from chronic symptoms such as fatigue or shortness of breath. As researchers have discovered, this is to some extent due to a part of our immune system called the complement system. The study identified a pattern in the blood proteins that will improve […]

The beneficial and pathogenic roles of complement in COVID-19

Alfred H.J. Kim, MD, PhD, Xiaobo Wu, MD and John P. Atkinson, MD Cleveland Clinic Journal of Medicine October 2020, DOI: ABSTRACT We briefly summarize the complement system and its functions in immunity and disease. We present data supporting the requirement of complement to resolve COVID-19, and discuss how complement overactivation later in severe disease could drive multiorgan damage characteristic of fatal COVID-19. INTRODUCTION The […]

Emerging role of complement in COVID‑19 and other respiratory virus Diseases

Mark T. Xiao1 · Calder R. Ellsworth· Xuebin Qin,: 3 February 2024 Abstract The complement system, a key component of innate immunity, provides the first line of defense against bacterial infection; however, the COVID-19 pandemic has revealed that it may also engender severe complications in the context of viral respiratory disease. Here, we review the […]

The complement system in COVID-19: friend and foe?

Anuja Java, Anthony J. Apicelli,,M. Kathryn Liszewski, Ariella Coler-Reilly, John P. Atkinson, Alfred H.J. Kim, and Hrishikesh S. Kulkarni; JCI Insight, 06 Aug 2020, 5(15):140711 PMID: 32554923 PMCID: PMC7455060 Introduction The emergence of the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has resulted in a rapid response from the global scientific community to better understand its pathophysiology […]

Could new clues on how long COVID affects immune system lead to treatment?

By Deep Shukla on January 28, 2024 Medical News Today Approximately 10%-20%Trusted Source of individuals with a SARS-CoV-2 infection experience lingering symptoms beyond three months after symptom onset. These symptoms referred to as long COVID, can be debilitating, but there is a lack of diagnostic or therapeutic tools. A new study published in Science found that patients experiencing long COVID symptoms six months after […]

Long Covid explanation in new study possibly paves way for tests and treatments

Scientists say that drugs that calm a key part of the immune system should be studied in clinical trials as potential long Covid treatments. Long Covid impacts some adults’ blood biomarkers, new study finds Jan. 18, 2024, By Barbara Mantel, Science Scientists have identified a persistent change in a handful of blood proteins in people with […]

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Authors: Luca Perico 1, Marina Morigi 1, et. al.; 2022 Mar 7;13:827146. doi: 10.3389/fimmu. 2022.827146. eCollection 2022. Abstract Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 to infect and replicate in endothelial cells, it has been poorly investigated whether, in the complexity of viral […]

C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps

Bruna M. Silva,1,2 Giovanni F. Gomes,1 Flavio P. Veras,1 Seppe Cambier,3 Gabriel V.L. Silva,1,2 Andreza U. Quadros,1 Diego B. Caetité,1,2 Daniele C. Nascimento,1,2 Camilla M. Silva,1,2 Juliana C. Silva,1 Samara Damasceno,1 Ayda H. Schneider,1 Fabio Beretta,3 Sabrina S. Batah,4 Icaro M.S. Castro,5 Isadora M. Paiva,1 Tamara Rodrigues,1,2 Ana Salina,1,6 Ronaldo Martins,6,7 Guilherme C.M. Cebinelli,1,2 Naira L. Bibo,1 Daniel M. Jorge,6,7 Helder I. Nakaya,5 Dario S. Zamboni,1,6 Luiz O. Leiria,1,2 Alexandre T. Fabro,4 José C. Alves-Filho,1,2 Eurico Arruda,6,7 Paulo Louzada-Junior,1,8 Renê D. Oliveira,1,8 Larissa D. Cunha,1,6 Pierre […]

Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

Authors: Bandar Alosaimi1,2, Ayman Mubarak3, Maaweya E. Hamed3, Abdullah Z. Almutairi4, Ahmed A. Alrashed5, Abdullah AlJuryyan6, Mushira Enani7,Faris Q. Alenzi8 and Wael Alturaiki9* COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve the complement pathway activation for cytokine storm development. Nevertheless, the role of complement in COVID-19 immunopathology, complement‐modulating treatment strategies against COVID-19, […]