John Murphy, M.D., MPH, D.P.H., President The COVID19 Long-haul Foundation AbstractA growing body of evidence implicates mitochondrial dysfunction — including depletion of mitochondrial DNA (mtDNA), loss of mitochondrial membrane potential, […]
Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution
2020 Jun;24(3):251-262. doi: 10.1007/s40291-020-00460-z. Walter Gottlieb Land 1 2 PMID: 32248387 PMCID: PMC7127836 DOI: 10.1007/s40291-020-00460-z Free PMC article Abstract This opinion article discusses the increasing attention paid to the role of activating damage-associated molecular patterns (DAMPs) […]
Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia
Review Article; Published: 17 June 2021 Authors: Walter Gottlieb Land Genes & Immunity volume 22, pages141–160 (2021 )Cite this article Abstract When surveying the current literature on COVID-19, the “cytokine storm” is considered to be […]
Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients
Authors: Joram Huckriede, Sara Bülow Anderberg, Albert Morales, Femke de Vries, Michael Hultström, Anders Bergqvist, José T. Ortiz-Pérez, Jan Willem Sels, Kanin Wichapong, Miklos Lipcsey, Marcel van de Poll, Anders Larsson, Tomas Luther, Chris Reutelingsperger, Pablo Garcia de Frutos, Robert Frithiof & Gerry A. F. Nicolaes Scientific […]
Inflammasome activation at the crux of severe COVID-19
Authors: Setu M. Vora,1,2Judy Lieberman,2,3 and Hao Wu1,2 Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly […]