Blood Vessels – Page 2 – The COVID-19 Long Haul Foundation

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

August 3, 2021 | John Murphy | Leave a Comment

Authors: Yuyang Lei, Jiao Zhang, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X., et. al. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Sprotein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium can be infected by […]

Clots, Strokes and Rashes: Is COVID a Disease of the Blood Vessels?

July 30, 2021 | John Murphy | Leave a Comment

Authors: Will Stone Whether it’s strange rashes on the toes or blood clots in the brain, the widespread ravages of COVID-19 have increasingly led researchers to focus on how the novel coronavirus sabotages blood vessels. As scientists have come to know the disease better, they have homed in on the vascular system — the body’s […]

The Thorny Problem Of COVID-19 Vaccines And Spike Proteins

July 30, 2021 | John Murphy | Leave a Comment

Authors: W. Glen Pyle Almost since the beginning of the COVID-19 pandemic, a piece of the SARS-CoV2 virus called the “spike protein” has drawn interest from researchers and healthcare professionals. New research by Yuyang Lei and colleagues published in the journal Circulation Research sheds new light on how the spike protein might play a critical role in […]

Evidence Shows that COVID-19 Attacks Blood Vessels

July 30, 2021 | John Murphy | Leave a Comment

Authors: Carolyn Crist As researchers learn more about COVID-19, they’ve seen reports from patients about unusual rashes, blood clots, and strokes, which could all be linked to damaged blood vessels. Scientists are now looking at the vascular system, which includes arteries, veins, and capillaries, to monitor the various ways that the coronavirus attacks the body, […]

COVID-19 is, in the end, an endothelial disease

July 30, 2021 | John Murphy | Leave a Comment

Authors: Peter Libby, Thomas Lüscher The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that normally maintain homeostasis. This tightly regulated palette of functions includes control of haemostasis, fibrinolysis, vasomotion, inflammation, oxidative stress, vascular permeability, and structure. While these functions participate in the moment-to-moment regulation […]

COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury

July 30, 2021 | John Murphy | Leave a Comment

Authors: Roberto F. Nicosia,∗∗ Giovanni Ligresti,† Nunzia Caporarello,‡ Shreeram Akilesh,∗ and Domenico Ribatti§ Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular complications characterized by thrombosis of small, medium, and large vessels. Dysfunction of the vascular endothelium due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated in the pathogenesis of the COVID-19 […]

Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy

July 30, 2021 | John Murphy | Leave a Comment

Authors: Jun Zhang 1, Kristen M Tecson 1, Peter A McCullough 1 2 3 Great attention has been paid to endothelial dysfunction (ED) in coronavirus disease 2019 (COVID-19). There is growing evidence to suggest that the angiotensin converting enzyme 2 receptor (ACE2 receptor) is expressed on endothelial cells (ECs) in the lung, heart, kidney, and intestine, particularly in systemic vessels (small and […]