Category: Blood Platelets

Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients 

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Stefania Campana; Claudia De Pasquale; Giacomo Sidoti Migliore;, et. al. J Immunol (2022) 209 (4): 655–659. https://doi.org/10.4049/jimmunol.2200021 Abstract Proinflammatory monocytes play a preponderant role in the development of a cytokine storm causing fatal consequences in coronavirus disease 2019 (COVID-19) patients, highlighting the importance of analyzing in more detail monocyte distribution in these patients. In this study, […]

Platelet Indices as Novel Surrogate Markers for the Prognosis of COVID-19 Infection: An Observational Study

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Vivek Lahane • Sourya Acharya • Samarth Shukla • et. al. June 12, 2024 DOI: 10.7759/cureus.62243  Abstract Background  The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe acute respiratory illness accountable for causing the coronavirus disease 2019 (COVID-19) illness. Thrombotic issues, acute respiratory distress syndrome (ARDS), and cytokine storm are significant contributors to morbidity and mortality in patients with COVID-19. Elevated D-dimer […]

People with Long COVID May Still Have Spike Proteins in Their Blood

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A possible biomarker for long COVID suggests some people with the condition never fully cleared the virus BY SASHA WARREN, Epidemiology; Scientific American The now infamous condition long COVID presents as a wide range of symptoms—everything from persistent chest pains to rashes, pins and needles, and brain fog. Doctors can diagnose long COVID by speaking to […]

Bone Marrow Suppression Secondary to the COVID-19 Booster Vaccine: A Case Report

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Authors: Toral Shastri 1, Navkiran Randhawa 2, Ragia Aly 3, Masood Ghouse 3 PMID: 35210894 PMCID: PMC8863340DOI: 10.2147/JBM.S350290 Abstract As of September 2021, SARS-CoV-2 booster shots became widely available in the US to ensure continued protection against the virus. A temporal relationship has been previously reported between the first or second dose of the COVID-19 vaccine and the development of thrombocytopenia. However, adverse events related […]

How To Increase Platelet Count In COVID Patients? What Is Thrombocytopenia?

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Authors: Ananya Varma Platelets are said to play an important role in inflammatory signalling. Here is why it is important to keep a check of Platelet count in COVID patients.  Given that COVID-19 is a relatively novel disease, newer research continues to emerge into its characteristics with scientists now linking rapidly decreasing platelets to be a symptom of […]

Thrombocytopenia following Pfizer and Moderna SARS‐CoV‐2 vaccination

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Authors: Eun‐Ju Lee, 1 Douglas B. Cines, 2 Terry Gernsheimer, 3 Craig Kessler, 4 Marc Michel, 5 Michael D. Tarantino, 6 John W. Semple, 7 Donald M. Arnold, 8 Bertrand Godeau, 5 Michele P. Lambert, 9 , 10 and James B. Bussel 11 Cases of apparent secondary immune thrombocytopenia (ITP) after SARS‐CoV‐2 vaccination with both the Pfizer and Moderna versions have been reported and reached public attention. Public alarm was heightened following the death of the first identified […]

Platelet Gene Expression and Function in COVID-19 Patients

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Authors: Bhanu Kanth Manne (University of Utah, United States) Frederik Denorme (Molecular Medicine Program, University of Utah, United States), Elizabeth Middleton (University of Utah, United States), Irina Portier (University of Utah, United States) Jesse Rowley (University of Utah, United, States) Chris Stubben (University of Utah, United States) Aaron Petrey (University of Utah, United States) Neal […]

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

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Authors: Si Zhang 1, Yangyang Liu 2, Xiaofang Wang 2, Li Yang 3, Haishan Li 4, Yuyan Wang 5, Mengduan Liu 2, Xiaoyan Zhao 2, Youhua Xie 5, Yan Yang 6, Shenghui Zhang 7, Zhichao Fan 8, Jianzeng Dong 2, Zhenghong Yuan 5, Zhongren Ding 2, Yi Zhang 9, Liang Hu 10 Abstract Background: Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events and […]

The Impact of COVID-19 Disease on Platelets and Coagulation

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Authors: Geoffrey D Wool 1, Jonathan L Miller 2 Abstract Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and […]

Dr. Charles Hoffe issues Vaccine warning… Deep dive on endothelial damage to blood vessels…

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Author: Dr. Charles Hoffe in a Coronavirus, that spike protein becomes part of the viral capsule. In other words, the cell wall around the virus, called the viral capsule. But it’s not in the virus. It’s in your cells. So it therefore becomes part of the cell wall of your vascular endothelium. Which means that […]