Category: Brain

Evaluation of Post–COVID-19 Cognitive Dysfunction: Recommendations for Researchers

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Jaqueline H. Becker, PhD1; Tracy D. Vannorsdall, PhD2; Sara L. Weisenbach, PhD3, JAMA Psychiatry. 2023;80(11):1085-1086. doi:10.1001/jamapsychiatry.2023.2820 SARS-CoV-2 infection is associated with increased rates of postillness cognitive dysfunction, colloquially referred to as “brain fog,”1 that may portend significant consequences for patient functioning and quality of life. Post–COVID-19 cognitive dysfunction is 1 of approximately 200 symptoms of post–COVID-19 condition (PCC), defined by the World Health Organization as […]

Self-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation

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Shelli F. Farhadian, MD, PhD1,2,3,4; Hailey D. Reisert, BS1; Lindsay McAlpine, MD3; et al, MA3,4 JAMA Netw Open. 2023;6(11):e2342741. doi:10.1001/jamanetworkopen.2023.42741 Introduction Long COVID, also known as post–COVID-19 condition (PCC), refers to a range of symptoms that may persist for weeks to months after acute COVID-19. A subset of people with PCC report neuropsychiatric symptoms (neuro-PCC); however, the mechanisms behind this phenomenon are not yet understood.1 Cerebrospinal […]

Dysgeusia in COVID-19: Possible Mechanisms and Implications

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Francina Lozada-Nur, DDS, MS, MPH,a Nita Chainani-Wu, DMD, MS, MPH, PhD,b Giulio Fortuna, DMD, PhD,c and Herve Sroussi, DMD, PhDd : Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Sep; 130(3): 344–doi: 10.1016/j.oooo.2020.06.016, PMCID: PMC7320705, PMID: 32703719 For the purpose of this letter to the editor, we will focus solely on new-onset dysgeusia as a potential early marker of COVID-19 infection and […]

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

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Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro-Almagro, Christoph Arthofer, Chaoyue Wang, et. al. Nature volume 604, pages697–707 (2022)Cite this article Abstract There is strong evidence of brain-related abnormalities in COVID-191,2,3,4,5,6,7,8,9,10,11,12,13. However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here we investigated brain changes in 785 […]

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

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Sydney R. Stein, Sabrina C. Ramelli, Alison Grazioli, Joon-Yong Chung, Manmeet Singh, Claude Kwe Yinda, Clayton W. Winkler, Junfeng Sun, James M. Dickey, Kris Ylaya, Sung Hee Ko, et. al. Nature volume 612, pages758–763 (2022)Cite this article Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction1,2,3 during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients experiencing prolonged symptoms, termed post-acute sequelae of SARS-CoV-2 […]

Autopsies show COVID-19 virus in brain, elsewhere in body

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Jim Wappes, December 15, 2022 University of Minnesota An analysis of tissue samples from the autopsies of 44 people who died with COVID-19 shows that SAR-CoV-2 virus spread throughout the body—including into the brain—and that it lingered for almost 8 months. The study was published yesterday in Nature. Scientists from the National Institutes of Health (NIH) tested samples […]

Long COVID: Antibodies in cerebrospinal fluid linked with brain fog

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Deep Shukla, 2022 Medical News Today Coronavirus data Brain fog, or cognitive dysfunction, is one of the most common symptoms that health professionals observe in individuals with long COVID, or post-acute COVID-19. A recent study by researchers at the University of California, San Francisco (UCSF) suggests a link between the presence of persistent cognitive symptoms several months after a SARS-CoV-2 […]

COVID: The Science™ Concedes the Shots Cause Strokes

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NOV 06, 2023 – Originally published  Armageddon Prose: COVID Shots Cause Strokes, The Science™ Concedes “Older adults who received last year’s COVID booster and a high-dose version of the flu vaccine in a recent study may have a potential increased risk of stroke, according to a new FDA-funded research project. Experts urged that the results […]

Pathophysiology, diagnosis, and management of neuroinflammation in covid-19

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BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2022-073923 (Published 18 August 2023)Cite this as: BMJ 2023;382:e073923, Rachel L Brown123,  Laura Benjamin24,  Michael P Lunn12,  Tehmina Bharucha25,  Michael S Zandi12,  Chandrashekar Hoskote6,  Patricia McNamara2,  Hadi Manji1 Abstract Although neurological complications of SARS-CoV-2 infection are relatively rare, their potential long term morbidity and mortality have a significant impact, given the large numbers of infected patients. Covid-19 is […]

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition

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Authors: Peng Pi1† Zhipeng Zeng1† Liqing Zeng1 Bing Han1 Xizhe Bai2 Shousheng Xu3*Front. Pharmacol., 03 August 2023, Sec. Respiratory Pharmacology, Volume 14 – 2023 | https://doi.org/10.3389/fphar.2023.1218059 As the outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in Hubei Province, China, at the end of 2019. It has brought great challenges and harms to global […]