John Murphy, M.D., M.P.H., D.P.H. President COVID-19 Long-haul Foundation Abstract Long COVID, also termed post-COVID condition or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as one of the most […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Severe cerebral amyloid angiopathy related inflammation (CAA-ri) associated with vaccination
Michael Tang 1, Jane Kim 2, Kui Kai Lau 3, Koon Ho Chan 3, PMID: 39094435, DOI: 10.1016/j.jneuroim.2024.578406 Abstract Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rapid but reversible autoimmune encephalopathy where spontaneous autoantibody reaction against amyloid beta deposited […]
Scientists uncover biological cause of Long COVID brain fog in major breakthrough
By Theo Farrant New research offers what scientists describe as the first biological evidence of Long COVID brain fog. Scientists in Japan have identified a potential biological cause of Long COVID brain fog, […]
Chronic Inflammation Pathways Identified in Long COVID
I. Persistent Cytokine-Driven Inflammatory Signaling I.A. IL-6–Centered Inflammatory Axis Interleukin-6 (IL-6) has emerged as one of the most consistently elevated cytokines in Long COVID cohorts, serving as a central node […]
Inflammatory Markers as Predictors of Onset and Recovery of Olfactory and Gustatory Dysfunction in COVID-19 Patients
Burak Celik • Fatih Gul • Hacı Huseyin Dere, DOI: 10.7759/cureus.96003 Abstract Background Olfactory and gustatory dysfunctions are widely recognized as characteristic manifestations of COVID-19. However, the relationship between disease severity, inflammatory markers, and the […]
Inflammation: The Molecular Convergence of Gout, COVID-19, and Uric Acid Metabolism
Inflammation is not merely a symptom—it is a biological imperative. It orchestrates the body’s defense against infection, injury, and metabolic imbalance. Yet when dysregulated, inflammation becomes a crucible for chronic […]
Endothelial Dysfunction and Spike Protein Persistence in Long COVID: Mechanisms, Vulnerabilities, and Clinical Evidence
Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms affecting multiple organ systems. Among its most compelling […]
Transcriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis
Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disease linked with deregulated immune responses, leading to hyperinflammation, acute respiratory distress syndrome, and pulmonary fibrosis, often with fatal outcomes. Neutrophils […]
Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy
Baneet Kaur • Cyril Blavo • Mayur S. Parmar, DOI: 10.7759/cureus.56025 Abstract Ivermectin was first discovered in the 1970s by Japanese microbiologist Satoshi Omura and Irish parasitologist William C. Campbell. Ivermectin has become a versatile […]