Category: Colchicine

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]

Potential Prophylactic Treatments for COVID-19

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Noam Ben-Zuk,1,† Ido-David Dechtman,2,3,† Itai Henn,1 Libby Weiss,1 Amichay Afriat,4 Esther Krasner,1,* and Yoav Gal1,5,*Kenneth Lundstrom, Academic Editor and Alaa A. A. Aljabali, Academic Editor Viruses. 2021 Jul; 13(7): 1292. Published online 2021 Jul 2. doi: 10.3390/v13071292 PMCID: PMC8310088 PMID: 34372498 Abstract The World Health Organization declared the SARS-CoV-2 outbreak a Public Health Emergency of International Concern at the end of January 2020 and a pandemic two months later. The […]

Colchicine: A Possible COVID-19 Long haul Cardiac Therapy

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Last Updated: December 16, 2021 Last Updated: December 16, 2021 Colchicine is an anti-inflammatory drug that is used to treat a variety of conditions, including gout, recurrent pericarditis, and familial Mediterranean fever.1 Recently, the drug has been shown to potentially reduce the risk of cardiovascular events in those with coronary artery disease.2 Colchicine has several potential mechanisms of action, […]

The Role of Colchicine in Pericardial Syndromes

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Authors: George Lazaros 1, Massimo Imazio 2, Antonio Brucato 3, Charalambos Vlachopoulos 1, Emilia Lazarou 1, Dimitrios Vassilopoulos 4, Dimitris Tousoulis 1PMID: 29336245 DOI: 10.2174/1381612824666180116101823 Curr Pharm Des . 2018;24(6):702-709. doi: 10.2174/1381612824666180116101823. Abstract Background: Colchicine is an old drug originally employed for the treatment of inflammatory disorders such as acute gout and familiar Mediterranean fever. Methods: In the past few decades, colchicine has been at the forefront of the pharmacotherapy of several […]

Colchicine Treatment for Recurrent Pericarditis

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A Decade of Experience Authors: Y. Adler, Y. Finkelstein, J. Guindo, A. Rodriguez de la Serna, Y. Shoenfeld, A. Bayes-Genis, A. Sagie, A. Bayes de Luna and D. H. SpodickOriginally published2 Jun 1998 https://doi.org/10.1161/01.CIR.97.21.2183 Circulation. 1998;97:2183–2185 Abstract Background—The most troublesome complication of acute pericarditis is recurrent episodes of pericardial inflammation, occurring in 15% to 32% of cases. The cause of the recurrence is usually […]

Colchicine could cut COVID-19 deaths – Israeli scientist

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Authors: By MAAYAN JAFFE-HOFFMAN Published: DECEMBER 14, 2021 17:37 An ancient Greek drug derived from the saffron plant could improve the treatment of people with severe COVID-19 and reduce the COVID mortality rate by as much as 50%, according to a report published earlier this month in the European Journal of Internal Medicine by an Israeli researcher from the Hebrew University of […]

COVID-19 also attacks the pancreas; one vaccine dose may be enough for those previously infected

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Authors: Nancy Lapid February 3, 2021 COVID-19 attacks the pancreas The new coronavirus directly targets the pancreas, infecting and damaging its insulin producing cells, according to a new study. The findings may help explain why blood sugar problems develop in many COVID-19 patients, and why there have been reports of diabetes developing as a result […]