Category: Apoptosis

Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases

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Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox & Avik Roy  Infectious Agents and Cancer volume 18, Article number: 7 (2023) Cite this article, A Correction to this article was published on 24 April 2023 Abstract Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze […]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng  Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Cite this article 17 October 2022 Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that […]

An overview of human proteins and genes involved in SARS-CoV-2 infection

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Zohreh Jahanafrooz,a,⁎ Zhishan Chen,b Jiandong Bao,c Hongzhi Li,d Loren Lipworth,b and Xingyi Guob,e,⁎Gene. 2022 Jan 15; 808: 145963. Published online 2021 Sep 14. doi: 10.1016/j.gene.2021.145963 PMCID: PMC8437745PMID: 34530086 Graphical abstract A summarized view of recent findings of host proteins interacting with SARS-CoV-2 and genes containing associated variants with COVID-19 susceptibility and severity. The left side of the figure (A) shows host protein interactors (blue wrote) for […]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]

COVID-19 can trigger auto-immune disorders-related antibodies, causing thrombosis and other complications

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SEPTEMBER 12, 2023 by Maria Fernanda Ziegler, FAPESP Medical Express An article published in npj Aging reveals that natural production of auto-antibodies increases with age, and that infection by SARS-CoV-2 can exacerbate production of auto-antibodies relating to auto-immune diseases, helping to explain why aging increases the chances of developing severe COVID-19. The study also discovered some of the factors that […]

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

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Authors : Mirren Charnley, Saba Islam,  Guneet K. Bindra,  Jeremy Engwirda,  Julian Ratcliffe,  Jiangtao Zhou,  Raffaele Mezzenga,  Mark D. Hulett,  Kyunghoon Han,  Joshua T. Berryman & Nicholas P. Reynolds  Nature Communications volume 13, Article number: 3387 (2022)  July 2022 Abstract COVID-19 is primarily known as a respiratory disease caused by SARS-CoV-2. However, neurological symptoms such as memory loss, sensory confusion, severe headaches, and […]

Analysis of the Study of the Expression of Apoptosis Markers (CD95) and Intercellular Adhesion Markers (CD54) in Healthy Individuals and Patients Who Underwent COVID-19 When Using the Drug Mercureid

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Authors: Sergey N Gusev1*, Velichko LN2, Bogdanova AV2, Khramenko NI2, Konovalova NV2 Published Date: 26-08-2021 Abstract SARS-CoV-2, the pathogen, which is responsible for coronavirus disease 2019 (COVID-19), has caused unprecedented morbidity and mortality worldwide. Scientific and clinical evidence testifies about long-term COVID-19 effects that can affect many organ systems. Cellular damage, overproduction of proinflammatory cytokines and […]

Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational study

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Authors: Brandon Michael Henry1, http://orcid.org/0000-0002-1211-8247Isaac Cheruiyot2, Stefanie W Benoit3,4, Fabian Sanchis-Gomar5,6, http://orcid.org/0000-0001-9523-9054Giuseppe Lippi7, Justin Benoit8 Correspondence to Dr Brandon Michael Henry, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA; Abstract Background The mechanism by which SARS-CoV-2 triggers cell damage and necrosis are yet to be fully elucidated. We sought to quantify epithelial cell death in patients with COVID-19, with an estimation of […]

Inflammasome activation at the crux of severe COVID-19

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Authors: Setu M. Vora,1,2Judy Lieberman,2,3 and Hao Wu1,2 Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as obesity and diabetes. Severe disease is characterized by dysregulated cytokine release, pneumonia and acute lung injury, which can […]