Category: interferon β (IFN-β),

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

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Rik G. H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, et. al.Nature (2024) Abstract The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, […]

Potential Prophylactic Treatments for COVID-19

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Noam Ben-Zuk,1,† Ido-David Dechtman,2,3,† Itai Henn,1 Libby Weiss,1 Amichay Afriat,4 Esther Krasner,1,* and Yoav Gal1,5,*Kenneth Lundstrom, Academic Editor and Alaa A. A. Aljabali, Academic Editor Viruses. 2021 Jul; 13(7): 1292. Published online 2021 Jul 2. doi: 10.3390/v13071292 PMCID: PMC8310088 PMID: 34372498 Abstract The World Health Organization declared the SARS-CoV-2 outbreak a Public Health Emergency of International Concern at the end of January 2020 and a pandemic two months later. The […]

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

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Authors: Chansavath Phetsouphanh, David R. Darley, Daniel B. Wilson, Annett Howe, C. Mee Ling Munier, Sheila K. Patel, Jennifer A. Juno, Louise M. Burrell, Stephen J. Kent, Gregory J. Dore, Anthony D. Kelleher & Gail V. Matthews  Nature Immunology volume 23, pages210–216 (2022) June 30, 2022 Nature Immunology volume 23, pages210–216 (2022) Abstract A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer […]

New Clues To Long Covid: Prolonged Inflammatory Response

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Authors: William A. Haseltine January 2922 Posted July 2022 Forbes For many Covid-19 patients, the end of the acute stage of infection is only the beginning of another difficult experience: Long Covid. Defined by the persistence of physical and neuropsychiatric symptoms over a period of 12 weeks or longer, the exact causes of long Covid […]