Authors: the ISBT COVID-19 Working Group School of Medicine Abstract Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection, with group O […]
Role of neutrophil-epithelial interactions in SARS-CoV-2 infection
Authors: By Suchandrima BhowmikAug 15 2021Reviewed by Benedette Cuffari, M.Sc. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus that causes coronavirus disease 2019 (COVID-19), is associated with high […]
Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus
Authors: Igor Moshynskyy 1, Sathiyanarayanan Viswanathan, Natalia Vasilenko, Vladislav Lobanov, Martin Petric, Lorne A Babiuk, Alexander N Zakhartchouk Abstract Open reading frame 9b (ORF 9b) encodes a 98 amino acid group-specific protein of severe acute respiratory syndrome […]
The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus
Author links open overlay panelChristophMeier123A. RaduAricescu13ReneAssenberg2Robin T.Aplin2Robert J.C.Gilbert13Jonathan M.Grimes123David I.Stuart123 Summary To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is […]
UniProtKB – P59636 (ORF9B_SARS)
Protein: ORF9b protein database Gene: 9b Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli Functioni Plays a role in the inhibition of host innate […]
SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the AVS/TRAF3/TRAF6 signalosome
.J Immunol 2014 Sep 15;193(6):3080-9. doi: 10.4049/jimmunol.1303196. Epub 2014 Aug 18. Chong-Shan Shi 1, Hai-Yan Qi 2, Cedric Boularan 1, Ning-Na Huang 1, Mones Abu-Asab 3, James H Shelhamer 2, John H Kehrl 4 Abstract Coronaviruses (CoV) have recently emerged as potentially serious pathogens that […]
‘We are on fire’: Five U.S. states set new records for Covid cases as hospitalizations rise
PUBLISHED MON, AUG 16 20213:54 PM EDTUPDATED MON, AUG 16 20214:49 PM EDT KEY POINTS Nationwide, less than 11% of all hospital beds are being used by Covid patients. In […]
Inflammasome activation at the crux of severe COVID-19
Authors: Setu M. Vora,1,2Judy Lieberman,2,3 and Hao Wu1,2 Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly […]
No point vaccinating those who’ve had COVID-19: Cleveland Clinic study suggests
Authors: By Dr. Sanchari Sinha Dutta, Ph.D.Jun 8 2021 Scientists from the Cleveland Clinic, USA, have recently evaluated the effectiveness of coronavirus disease 2019 COVID-19) vaccination among individuals with or without […]
Mapping the human genetic architecture of COVID-19
COVID-19 Host Genetics Initiative, Nature (2021) Abstract The genetic makeup of an individual contributes to susceptibility and response to viral infection. While environmental, clinical and social factors play a role in […]