Category: Antibody dependent enhancement

Adverse effects of COVID-19 vaccines and measures to prevent them

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Authors: Kenji Yamamoto Virol J. 2022; 19: 100. Published online 2022 Jun 5. doi: 10.1186/s12985-022-01831-0 PMCID: PMC9167431PMID: 35659687 Abstract Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the […]

New coronavirus subvariants escape antibodies from vaccination and prior Omicron infection, studies suggest

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Authors: Jacqueline Howard, CNN June 23, 2022 Omicron subvariants BA.4 and BA.5 appear to escape antibody responses among both people who had previous Covid-19 infection and those who have been fully vaccinated and boosted, according to new data from researchers at Beth Israel Deaconess Medical Center, of Harvard Medical School. However, Covid-19 vaccination is still expected […]

The potential for antibody-dependent enhancement of SARS-CoV-2 infection: Translational implications for vaccine development

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Authors:  Jiong Wang andMartin S. Zand Published online by Cambridge University Press: 13 April 2020 Journal of Clinical and Translational Science>Volume 5 Issue 1 Abstract There is an urgent need for vaccines to the 2019 coronavirus (COVID19; SARS-CoV-2). Vaccine development may not be straightforward, due to antibody-dependent enhancement (ADE). Antibodies against viral surface proteins can, in some […]

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19

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Authors: Stephanie Seneff1 and Greg Nigh Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge MA, 02139, USA, E- Naturopathic Oncology, Immersion Health, Portland, OR 97214, ABSTRACT Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which […]

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

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Authors: Wen Shi Lee, Adam K. Wheatley, Stephen J. Kent & Brandon J. DeKosky  Nature Microbiology volume 5, pages1185–1191 (2020) Abstract Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). […]

A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies

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Authors: Gabriela Athziri Sánchez-Zuno,1,†Mónica Guadalupe Matuz-Flores,1,†Guillermo González-Estevez,1Ferdinando Nicoletti,2Francisco Javier Turrubiates-Hernández,1Katia Mangano,2 and José Francisco Muñoz-Valle1 Int J Immunopathol Pharmacol. 2021 Jan-Dec; 35: 20587384211050199.Published online 2021 Oct 10. doi: 10.1177/20587384211050199PMCID: PMC8512237PMID: 34632844 Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the […]

Antibody dependent enhancement: Unavoidable problems in vaccine development

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Authors: Lele Xu, Zhiqian Ma, Yang Li, Zhaoxia Pang, and Shuqi Xiao* Adv Immunol. 2021; 151: 99–133.Published online 2021 Sep 4. doi: 10.1016/bs.ai.2021.08.003 PMCID: PMC8438590PMID: 34656289 Abstract In some cases, antibodies can enhance virus entry and replication in cells. This phenomenon is called antibody-dependent infection enhancement (ADE). ADE not only promotes the virus to be recognized by the target cell and enters the target […]