Category: TGF-beta

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition

Posted on | Posted on John Murphy | Leave a Comment on Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition

Authors: Peng Pi1† Zhipeng Zeng1† Liqing Zeng1 Bing Han1 Xizhe Bai2 Shousheng Xu3*Front. Pharmacol., 03 August 2023, Sec. Respiratory Pharmacology, Volume 14 – 2023 | https://doi.org/10.3389/fphar.2023.1218059 As the outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in Hubei Province, China, at the end of 2019. It has brought great challenges and harms to global […]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

Posted on | Posted on John Murphy | Leave a Comment on Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion of symptomatic patients with post-coronavirus 2019 (COVID-19) condition (long COVID) represents a significant burden on the individual as well as on the health care systems. […]

Alzheimer’s-like signaling in brains of COVID-19 patients

Posted on | Posted on John Murphy | Leave a Comment on Alzheimer’s-like signaling in brains of COVID-19 patients

Authors: Steve Reiken,Leah Sittenfeld,Haikel Dridi,Yang Liu,Xiaoping Liu,Andrew R. Marks First published: 03 February 2022  https://doi.org/10.1002/alz.12558 Abstract Introduction The mechanisms that lead to cognitive impairment associated with COVID-19 are not well understood. Methods Brain lysates from control and COVID-19 patients were analyzed for oxidative stress and inflammatory signaling pathway markers, and measurements of Alzheimer’s disease (AD)-linked […]