John Murphy, M.D., M.P.H., D.P.H. CEO COVID Long-haul Foundation Abstract Background Long COVID, also termed Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), is a complex multisystem disorder characterized by persistent symptoms […]
COVID-19–Associated Transverse Myelitis: Immunopathogenesis, Genomic Susceptibility, Clinical Phenotypes, Diagnostic Advances, Therapeutic Strategies, and Long-Term Outcomes
Abstract Transverse myelitis (TM) is an inflammatory disorder of the spinal cord characterized by acute or subacute development of bilateral motor, sensory, and autonomic dysfunction attributable to focal spinal cord […]
Long COVID and Autonomic Nervous System Dysfunction
John Murphy, CEO The COVID-19 Long-haul Foundation Abstract Post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID, represents a multisystem disorder characterized by persistent, relapsing, or new-onset symptoms extending […]
Progressive Neuropathy in Long COVID: Etiology, Pathogenesis, Genomics, Clinical Evolution, Therapeutic Strategies, and Vaccine Implications
Abstract Post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID, represents one of the largest emerging chronic disease burdens of the twenty-first century. Although pulmonary and cardiovascular manifestations initially […]
Peripheral Sensory Dysfunction in Long COVID: Etiology, Genomics, Pathophysiology, Clinical Manifestations, Diagnostic Approaches, Disease Progression, and Long-Term Outcomes
John Murphy, MD., M.P.H., D.P.H., CEO, COVID-19 long-haul Foundation Abstract Long COVID, also known as Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), has emerged as one of the most significant chronic […]
COVID-19 and Loss of Sensory-motor Function
John Murphy, CEO Covid 10 Long-haul Foundationn Loss of sensory-motor function affecting the hands, arms, legs, and feet has become one of the more disabling neurological manifestations reported after acute […]
COVID-19 and the Motor–Sensory Brain: Pathobiology, Microvascular Injury, Neurophysiology, Clinical Manifestations, Therapeutic Strategies, and Long-Term Outcomes
John Murphy, CEO COVID-19 Long-haul Founndation Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), initially characterized as a respiratory pathogen, is now recognized as a systemic vascular and neurotropic disease […]
NIH RECOVER Clinical Trials and the First Emergence of Interventional Results in Long COVID Research: A Translational Turning Point
A Scholarly Review for Scientific American (Submission-Style Manuscript) John Murphy, M.D., M.P.H., D.P.H., President, COVID-19 Long-Haul Foundation Abstract The NIH RECOVER Initiative represents the largest coordinated research program investigating post–acute […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
COVID-19–Associated Neuropathy of the Feet and Legs: Etiology, Pathophysiology, Clinical Course, and Therapeutic Approaches
Abstract Peripheral neuropathy involving the feet and legs has emerged as one of the most prevalent and disabling neurological sequelae associated with acute and post-acute COVID-19 illness. Although initially overshadowed […]