When the Lights Go Out: Long COVID, Transient Loss of Consciousness, Cerebral Hypoperfusion, and the Neurology of the “Blackout”

John Murphy, CEO The COVID-19 Long haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), has increasingly revealed itself as a disorder extending well beyond pulmonary injury. […]

Brain / CNS / Inflammatory neuropathy / Nerve Cell Injury / Neurodegeneration / Neuroinflammation / Neurologic / Neurologic Effects / Neurology / Pathobiological / Pathology / Pathophysiology Posted on: October 9, 2026September 3, 2026

The Neurological Sequelae of COVID-19: Long-Term Injury to the Central Nervous System, Neuroimaging, Neuropathology, and Emerging Mechanisms of Long COVID

John Murphy, CEO The COVID-19 Long-haul Foundation Introduction The neurological consequences of SARS-CoV-2 infection have evolved from an initially unexpected collection of clinical observations into a substantial body of neuropathological, […]

CNS / Neuropathy / Peripheral neuropathy / Small fiber neuropathy Posted on: October 7, 2026September 1, 2026

Long COVID and Peripheral Neuropathy

John Murphy, CEO The COVID-19 Long haul Foundation Abstract Post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID, encompass a heterogeneous constellation of neurological, autonomic, cardiovascular, respiratory, gastrointestinal, musculoskeletal […]

CNS / Dysautonomia / Vagus Nerve Posted on: October 4, 2026September 1, 2026

When the Virus Leaves but the Darkness Remains

COVID-19, Long COVID, and the Biology of Persistent Depression A comprehensive clinical and mechanistic review John Murphy, CEO The COVID-19 Long haul Foundation Abstract Depression has emerged as one of […]

Brain / CNS / Neurocognitive / Neurodegeneration / Neuroinflammation / Neurologic / Neurologic Effects / Neuromodulation / Neuropathy Posted on: September 14, 2026August 25, 2026

Neurological Long COVID

John Murphy, CEO, The COVID-19 Long haul Foundation A mechanistic synthesis of post-acute neurological sequelae of SARS-CoV-2 infection Abstract Neurological manifestations constitute one of the most consequential and biologically heterogeneous […]

Cardiovascular / Fatigue / Gastrointestinal / Inflammation / Metabolic Dysregulation / Neurocognitive / Neuropathy / Phenotype / Postural Orthostatic Tachycardia (POTS) / Respiratory Syndrome / Vascular System Posted on: September 12, 2026August 23, 2026

Long COVID as a Spectrum of Distinct Biological Phenotypes

A mechanistic synthesis of the emerging phenotype-based model of post-acute sequelae of SARS-CoV-2 infection John Murphy, CEO The COVID-19 Long haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 […]

Autonomic dysfunction / Autonomic nerves / Autonomic nervous system disruption / Cardiovascular System / Central autonomic network / CNS / Dysautonomia / Vagus Nerve Posted on: September 3, 2026September 1, 2026

COVID-19 and Dysautonomia: From Vagal Injury to Systemic Physiological Failure

A narrative review of autonomic dysfunction, vagal disruption, pathophysiology and clinical course in Long COVID Abstract Background: Dysautonomia has emerged as one of the most consequential neurological and cardiovascular manifestations […]

Abnormal sweating / Allodynia / Autonomic dysfunction / Balance / Burning pain / CNS / Dysesthesia / Gait / Gastrointestinal / Genitourinary / Neuropathy / Numbness / Orthostatic intolerance / Paresthesia Posted on: August 23, 2026August 12, 2026

Long COVID and Peripheral Neuropathy: Clinical Phenotypes, Pathobiology, Diagnosis, and Treatment

John Murphy, CEO, The Covid-19 Long Haul Foundation A Narrative Review Abstract Importance: Peripheral nervous system dysfunction is increasingly recognized among the neurological manifestations of Long COVID. Small-fiber neuropathy (SFN), […]

Acute transverse myelitis / Axonal Injury / Blood brain barrier / Concerns / Cytokine Storm / Encephalomyelitis / Encephalopathy / Epidemiology / Gray matter / Guillain Barre / Guillian-Barre Syndrome / Inflammation / Ischemic Stroke / Neurologic Effects / Neuromyelitis optica / Oligodendrocyte injury / Oxidative stress / Transverse Myelitis / Vaccine Enhanced Disease / Vaccine News / Vaccine Safety / White matter Posted on: August 18, 2026August 9, 2026

Transverse myelitis:Genomics, Cell Biology, Clinical Manifestations, Diagnosis, Treatment, and Long-Term Prognosis

Author: John Murphy, CEO, The COVID-19 Long Haul Foundation Abstract Background Transverse myelitis (TM) is an uncommon inflammatory disorder of the spinal cord characterized by acute or subacute neurological dysfunction […]

Autonomic nerves / Autonomic nervous system disruption / Central autonomic network / CNS / Dysautonomia / Endothelium / Etiology / Gastrointestinal / Immune Modulators / Immune System / Immunopathology / Mitochondrial depletion / Orthostatic intolerance / Outcomes / Pathology / Pathophysiology / Postural Orthostatic Tachycardia (POTS) / Sleep Disturbance / Tachycardia / Temperature / Treatments / Vagus Nerve Posted on: August 2, 2026July 16, 2026

Long COVID and Dysautonomia: Emerging Insights Into Autonomic Dysfunction, Vagal Pathobiology, Neuroimmune Interactions, and Therapeutic Strategies

John Murphy, M.D., M.P.H., D.P.H. CEO COVID Long-haul Foundation Abstract Background Long COVID, also termed Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), is a complex multisystem disorder characterized by persistent symptoms […]