Category: Macrophage

Role of MicroRNA-21 in Regulating Intracellular Pathways Associated With Phagocytosis in Human Macrophages: An In Vitro Study

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Natsuki Anada • Yoshinobu Nakayama • Jun Takeshita • Kyoko Kageyama • Hiroatsu Sakamoto • Takahiko Kamibayashi • Yasufumi Nakajima 2024, DOI: 10.7759/cureus.63736  Abstract Introduction The efficient clearance of bacteria by macrophages is crucial for the timely resolution of inflammation. In this study, we investigated the role of microRNA-21 (miR-21)-induced phagocytosis and its intracellular signaling pathways in human macrophages in vitro. Methods Human peripheral blood mononuclear cells (PBMCs) were […]

Scientists Gain Insight Into COVID’s Heart Impact

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(02 October 2023 Newsmax Health Day New research shows the COVID-19 virus can directly infect coronary arteries, inflaming fatty plaque inside them, which can increase the risk of heart disease and stroke. This may explain why some people who get COVID-19 have a greater chance of developing heart disease. It also may shed light on […]

Trained Innate Immunity, Epigenetics, and Covid-19

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Authors: Alberto Mantovani, M.D., and Mihai G. Netea, M.D. Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in tissue repair and resistance against pathogens.1 Exposure to selected vaccines, such as bacille Calmette–Guérin (BCG) or microbial components, can increase the baseline tone of innate immunity and trigger […]