Category: Blood

Role of MicroRNA-21 in Regulating Intracellular Pathways Associated With Phagocytosis in Human Macrophages: An In Vitro Study

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Natsuki Anada • Yoshinobu Nakayama • Jun Takeshita • Kyoko Kageyama • Hiroatsu Sakamoto • Takahiko Kamibayashi • Yasufumi Nakajima 2024, DOI: 10.7759/cureus.63736  Abstract Introduction The efficient clearance of bacteria by macrophages is crucial for the timely resolution of inflammation. In this study, we investigated the role of microRNA-21 (miR-21)-induced phagocytosis and its intracellular signaling pathways in human macrophages in vitro. Methods Human peripheral blood mononuclear cells (PBMCs) were […]

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

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Authors: Luca Perico1†, Marina Morigi1†, Miriam Galbusera1, et. al. Frontiers in Immunology March 2922 Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 to infect and replicate in endothelial cells, it has been poorly investigated whether, in the complexity of viral infection in […]

Dynamic Assessment of Hematological Parameters as Predictive Biomarkers for Disease Severity and Prognosis in COVID-19 Patients: A Longitudinal Study

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Aparna P. Patange • Jabbar V. Desai • Bhupal Pujari • Aparna Marwah • Animesh Dey, Published: July 01, 2024, DOI: 10.7759/cureus.63593  Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to substantial morbidity and mortality worldwide. Hematological abnormalities are common in COVID-19 patients and play a significant role in disease pathogenesis and prognosis. Objective: […]

COVID’s Long Haul: Virus Lingers in Blood Years After Infection

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Featured Neurology Neuroscience, March 7, 2024 Summary: SARS-CoV-2, the virus responsible for COVID-19, can persist in the blood and tissue of some patients for up to two years post-infection, offering new insights into the phenomenon of long COVID. This groundbreaking research found COVID antigens in blood samples up to 14 months after infection and in tissue […]

Clinical Significance of CBC and WBC Morphology in the Diagnosis and Clinical Course of COVID-19 Infection 

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Olga Pozdnyakova, MD, PhD, Nathan T Connell, MD, MPH, Elisabeth M Battinelli, MD, PhD, Jean M Connors, MD, Geoffrey Fell, MS, Annette S Kim, MD, PhD, American Journal of Clinical Pathology, Volume 155, Issue 3, March 2021, Pages 364–375, https://doi.org/10.1093/ajcp/aqaa231 Abstract Objectives To investigate the clinical significance of numeric and morphologic peripheral blood (PB) changes in coronavirus disease 2019 (COVID-19)–positive patients […]

Hematological alterations associated with long COVID-19

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Guilherme C. Lechuga1,2,3Carlos M. Morel1Salvatore Giovanni De-Simone1,2,4*, Front. Physiol., 23 July 2023Sec. Red Blood Cell Physiology, Volume 14 – 2023 | https://doi.org/10.3389/fphys.2023.1203472 Long COVID-19 is a condition characterized by persistent symptoms lasting beyond the acute phase of COVID-19. Long COVID-19 produces diverse symptomatology and can impact organs and systems, including the hematological system. Several studies have […]

UCSF Researchers Identify Major Driver Behind COVID And Long COVID, With Potential Treatment

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Authored by Marina Zhang via The Epoch Times Researchers at the University of California San Francisco have identified fibrin, a natural protein involved in blood clotting, as a major driver of the COVID-19 disease, according to a new study. Fibrin binds to proteins from the SARS-CoV-2 virus to form blood clots that are difficult to break down, the […]

A Case Report Highlighting the Significance of COVID-19 Unveiling Megaloblastic Anemia and Worsening Dementia in the Elderly

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Pooja Reddy • Pradeep Kumar Devarakonda • Gregory Gotlieb • Pedro Moreno: June 21, 2024,DOI: 10.7759/cureus.62836  Abstract The COVID-19 pandemic has resulted in substantial lifestyle changes with significant implications for nutritional health. Factors such as movement restrictions and disruptions in food supply chains led to the restricted availability of primary sources of essential micronutrients. To highlight this, we present the case of an […]

The blood holds clues to understanding long COVID

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The search for biomarkers could eventually lead scientists to tests and treatments By Meghan Rosen, MARCH 4, 2024 AT 9:00 AM Science News When I talk to immunologist Paul Morgan, he’s on the hunt for potentially life-altering drugs.  He’s got a call with a pharmaceutical company planned in the next half hour. His goal: persuade the company to […]

SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow

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Isabelle Allaeys, Guillaume Lemaire, Mickaël Leclercq, et. al. Blood Adv (2024) 8 (11): 2777–2789. Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow (BM) and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence MK transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated […]