The blood holds clues to understanding long COVID


The search for biomarkers could eventually lead scientists to tests and treatments By Meghan Rosen, MARCH 4, 2024 AT 9:00 AM Science News When I talk to immunologist Paul Morgan, he’s on the hunt for potentially life-altering drugs.  He’s got a call with a pharmaceutical company planned in the next half hour. His goal: persuade the company to […]

SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow


Isabelle Allaeys, Guillaume Lemaire, Mickaël Leclercq, et. al. Blood Adv (2024) 8 (11): 2777–2789. Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow (BM) and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence MK transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated […]

The blood holds clues to understanding long COVID


The search for biomarkers could eventually lead scientists to tests and treatments By Meghan Rosen, MARCH 4, 2024 Science News When I talk to immunologist Paul Morgan, he’s on the hunt for potentially life-altering drugs.  He’s got a call with a pharmaceutical company planned in the next half hour. His goal: persuade the company to supply his lab […]

Retrospective Evaluation of Hematological Parameters in COVID-19 Patients: Insights From the Emergency Department


Ahmed Jerah, May 28, 2024, DOI: 10.7759/cureus.61258 Cite this article as: Jerah A (May 28, 2024) Retrospective Evaluation of Hematological Parameters in COVID-19 Patients: Insights From the Emergency Department. Cureus 16(5): e61258. doi:10.7759/cureus.61258 Abstract Background: This retrospective study evaluated hematological parameters in coronavirus disease 2019 (COVID-19) patients to gain clinical insights. Methods: Data from the Emergency Department of Samtah […]

Blood cell morphology and COVID-19 clinical course, severity, and outcome


Published: 05 July 2021, Volume 14, pages 221–228, (2021), Journal of Hematopathology, Amirhossein Pezeshki, Atefeh Vaezi & Pardis Nematollahi  Abstract COVID-19 infection affects different organs of the human body, and blood cells are not an exception. Peripheral blood smear (PBS) is a simple and available method to investigate blood cells’ morphologic changes. In this study, we aimed to determine the morphologic […]

Japanese Preprint Calls For mRNA COVID -19 Vaccines To Be Suspended Over Blood Bank Contamination Concerns


MAR 23, 2024 – Authored by Naveen Athrappully via The Epoch Times  Receiving blood transfusion from COVID-19-vaccinated individuals could pose a medical risk to unvaccinated recipients since numerous adverse events are being reported among vaccinated people worldwide, according to a recent study from Japan. The preprint review, published on March 15, examined whether receiving blood from COVID-19-vaccinated […]

Anemia in patients with Covid-19: pathogenesis and clinical significance


Gaetano Bergamaschi 1, Federica Borrelli de Andreis 2 3, et.al. Observational Study Clin Exp Med2021 May;21(2):239-246. doi: 10.1007/s10238-020-00679-4. Epub 2021 Jan 8. Abstract COVID-19 patients typically present with lower airway disease, although involvement of other organ systems is usually the rule. Hematological manifestations such as thrombocytopenia and reduced lymphocyte and eosinophil numbers are highly prevalent in COVID-19 and have prognostic significance. Few data, […]

People with Long COVID May Still Have Spike Proteins in Their Blood


A possible biomarker for long COVID suggests some people with the condition never fully cleared the virus BY SASHA WARREN, Epidemiology; Scientific American The now infamous condition long COVID presents as a wide range of symptoms—everything from persistent chest pains to rashes, pins and needles, and brain fog. Doctors can diagnose long COVID by speaking to […]

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization


Maxime Taquet, Zuzanna Skorniewska, Adam Hampshire, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Parisa Mansoori, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, PHOSP-COVID Study Collaborative Group,  Nature Medicine (August 2023)  Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and […]

Treatment of Long COVID symptoms with triple anticoagulant therapy


Gert J Laubscher, M Asad Khan, Chantelle Venter, Jan H Pretorius, and 2 more, This is a preprint; it has not been peer reviewed by a journal. https://doi.org/10.21203/rs.3.rs-2697680/v1 Research Square Abstract Background: Fibrin(ogen) amyloid microclots and platelet hyperactivation are key pathological findings in patients with acute COVID-19 infection and also in those with Long COVID/Post-Acute Sequelae […]