Authors: Giuseppe Pascarella 1, Alessandro Strumia 1, Chiara Piliego 1, Federica Bruno 1, Romualdo Del Buono 2, Fabio Costa 1, Simone Scarlata 3, Felice Eugenio Agrò Severe acute respiratory syndrome coronavirus (SARS-CoV)-2, a novel coronavirus from the same family as SARS-CoV and Middle East […]
COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options
Authors: Larissa E van Eijk, 1 , † Mathijs Binkhorst, 2 , † Arno R Bourgonje, 3 , ‡ Annette K Offringa, 4 , ‡ Douwe J Mulder, 5 Eelke M Bos, 6 Nikola Kolundzic, 7 , 8 Amaal E Abdulle, 5 Peter HJ van der Voort, 9 Marcel GM Olde Rikkert, 10 Johannes G […]
Can COVID-19 Immunity Last for Years?
Author: Christina Aungst, PharmD Key takeaways: People who were sick with COVID-19 and recovered might have long-term immunity that lasts for months or years. We don’t know how long vaccine […]
SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy
Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak significantly delaying the hope for the virus’ complete eradication. In the absence of effective vaccines, we need effective treatments with […]
What is the role of T cells in COVID-19 infection? Why immunity is about more than antibodies
Summary CD4+ T cells help B cells to produce antibodies and help CD8+ T cells to kill virus-infected cells One of the dominant cytokines produced by T cells is interferon […]
T cell responses in patients with COVID-19
The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies […]
Understanding How COVID-19 Vaccines Work
How COVID-19 Vaccines Work COVID-19 vaccines help our bodies develop immunity to the virus that causes COVID-19 without us having to get the illness. Different types of vaccines work in […]
Immune T Cells May Offer Lasting Protection Against COVID-19
Much of the study on the immune response to SARS-CoV-2, the novel coronavirus that causes COVID-19, has focused on the production of antibodies. But, in fact, immune cells known as memory […]
COVID-19 Attacks Endothelial Cells
The pandemic virus SARS-CoV-2 can enter the body via cells in the nose to cause the illness COVID-19. But we know now that it doesn’t stop there. Clinicians and scientists have found […]
The Specter of Endothelial Injury in COVID-19
Studies signal that damage to the endothelium—cells that cover blood vessels like wallpaper—could underpin the thrombosis and inflammation induced by coronavirus infection. The endothelium as a common theme in COVID-19 […]