Category: Inflammation

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition

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Authors: Peng Pi1† Zhipeng Zeng1† Liqing Zeng1 Bing Han1 Xizhe Bai2 Shousheng Xu3*Front. Pharmacol., 03 August 2023, Sec. Respiratory Pharmacology, Volume 14 – 2023 | https://doi.org/10.3389/fphar.2023.1218059 As the outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in Hubei Province, China, at the end of 2019. It has brought great challenges and harms to global […]

COVID-19 Vaccines ‘May Trigger’ Rheumatic Inflammatory Diseases: Study

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OCT 15, 2023 – Authored by Marina Zhang via The Epoch Times  A new review suggests that COVID vaccines “may trigger” rheumatic immune-mediated inflammatory diseases, including arthritis, vasculitis, lupus, and adult-onset Still’s disease. On average, patients developed rheumatic diseases 11 days after vaccine administration, according to the study. Seventy-five (over 27 percent) of these patients experienced […]

Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases

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Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox & Avik Roy  Infectious Agents and Cancer volume 18, Article number: 7 (2023) Cite this article, A Correction to this article was published on 24 April 2023 Abstract Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze […]

Long COVID scientists try to unravel blood clot mystery

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May 15, 202312:15 AM ET By Anil Oza, Rebecca Ramirez, Emily Kwong, Gabriel Spitzer, Margaret Cirino, Berly McCoy, https://www.npr.org/2023/05/10/1175217130/long-covid-scientists-try-to-unravel-blood-clot-mystery As part of studying long COVID, graduate researcher Bradley Wade Hamilton separates out microclots from blood platelets in a solution. The federal COVID-19 public health emergency ended last week, but millions in the U.S. — and across the globe — are still dealing […]

Serum vitamin D levels can be predictive of psoriasis flares up after COVID-19 vaccination: a retrospective case control study

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Emmanouil Karampinis1 George Goudouras1 Niki Ntavari1 Dimitrios Petrou Bogdanos2† Angeliki-Victoria Roussaki-Schulze1† Efterpi Zafiriou1*† Front. Med., 25 May 2023 Sec. Dermatology Volume 10 – 2023 | https://doi.org/10.3389/fmed.2023.1203426 Introduction: Many patients with chronic inflammatory dermatosis such as psoriasis usually ask about the safety of COVID-19 vaccination and if it would affect the course of their disease. Indeed, many case reports, case series and clinical […]

New onset and exacerbation of psoriasis after COVID-19 vaccination

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Nancy Wei, BA,a,∗ Mindy Kresch, BS,b Emily Elbogen, PA-C,c and Mark Lebwohl, MDc JAAD Case Rep. 2022 Jan; 19: 74–77. Published online 2021 Nov 29. doi: 10.1016/j.jdcr.2021.11.016 PMCID: PMC8628636 PMID: 34869811 Introduction The messenger RNA (mRNA)-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) vaccines were granted emergency use authorization during the ongoing COVID-19 pandemic by the United States Food and Drug Administration in December 2020.1 An adenoviral vector […]

COVID-19 can trigger auto-immune disorders-related antibodies, causing thrombosis and other complications

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SEPTEMBER 12, 2023 by Maria Fernanda Ziegler, FAPESP Medical Express An article published in npj Aging reveals that natural production of auto-antibodies increases with age, and that infection by SARS-CoV-2 can exacerbate production of auto-antibodies relating to auto-immune diseases, helping to explain why aging increases the chances of developing severe COVID-19. The study also discovered some of the factors that […]

Large COVID autopsy study finds SARS-CoV-2 all over the human body

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By Rich Haridy January 04, 2023 Source: National Institute of Allergy and Infectious Diseases A study found traces of the SARS-CoV-2 virus in over 80 different sites in the body In the most comprehensive autopsy tissue study conducted to date, researchers have found traces of the SARS-CoV-2 virus throughout the entire body, from the brain and the […]

Vagus nerve inflammation contributes to dysautonomia in COVID-19

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Marcel S Woo 1, Mohsin Shafiq 2, Antonia Fitzek 3, Matthias Dottermusch 2, Hermann Altmeppen 2, Behnam Mohammadi 2, Christina Mayer 1, Lukas C Bal 1, Lukas Raich 1, Jakob Matschke 2, Susanne Krasemann 2, Susanne Pfefferle 4, Thomas Theo Brehm 5 6, Marc Lütgehetmann 4, Julia Schädler 3, Marylyn M Addo 5 6 7, Julian Schulze Zur Wiesch 5 6, Benjamin Ondruschka 3, Manuel A Friese # 8, Markus Glatzel # 9 PMID: 37452829 PMCID: PMC10412500 DOI: 10.1007/s00401-023-02612-x Abstract Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes remain […]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

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Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion of symptomatic patients with post-coronavirus 2019 (COVID-19) condition (long COVID) represents a significant burden on the individual as well as on the health care systems. […]