Mitochondrial Depletion and Long-COVID: Etiology, Pathophysiology, Diagnostics, and Clinical Implications

February 5, 2026 | John Murphy | Leave a Comment

Mitochondrial Depletion and Long-COVID: Etiology, Pathophysiology, Diagnostics, and Clinical Implications

John Murphy, M.D., MPH, D.P.H., President The COVID19 Long-haul Foundation AbstractA growing body of evidence implicates mitochondrial dysfunction — including depletion of mitochondrial DNA (mtDNA), loss of mitochondrial membrane potential,…[...]

January 19, 2026 | John Murphy | Leave a Comment

COVID Fatigue: Etiology, Genomics, Physiology, Pathology, Neurobiology, Sleep Disturbance, Treatment, and Prognosis

John Murphy, CEO COVID-19 Long-haul Foundation Abstract Fatigue is the most prevalent and disabling symptom among survivors of SARS‑CoV‑2 infection, persisting in a substantial proportion of patients months to years…[...]

January 9, 2026 | John Murphy | Leave a Comment

Data-driven RECOVER research produces new discoveries about Long COVID.

This installment of the RECOVER Research Update—a summary of recent findings published every 3 months—focuses on innovative research using patient information contained in electronic health records (EHRs). Each time a person…[...]

November 5, 2025 | John Murphy | Leave a Comment

Neuroimmune Convergence in Narcolepsy and Long COVID-Associated ME/CFS

John Murphy, The COVID Long-haul Foundation Introduction Narcolepsy and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), particularly as it manifests in the context of Long COVID, represent two distinct clinical entities with…[...]

October 17, 2025 | John Murphy | Leave a Comment

First proposed blood test for chronic fatigue syndrome: what scientists think

A blood test has achieved 96% accuracy in diagnosing the condition in a small study of individuals. What does the test detect, and is it a biomarker of the condition?…[...]

September 22, 2025 | John Murphy | Leave a Comment

NIH-funded study finds cases of ME/CFS increase following SARS-CoV-2

New findings from the National Institutes of Health’s (NIH) Researching COVID to Enhance Recovery (RECOVER) Initiative suggest that infection with SARS-CoV-2, the virus that causes COVID-19, may be associated with…[...]

September 4, 2025 | John Murphy | Leave a Comment

The Lingering Pandemic: Mapping the Arc of Long COVID and the Search for Recovery

By John Murphy, The COVID 19 Long-haul Foundation Introduction: A Pandemic That Didn’t End When the world first confronted SARS-CoV-2 in early 2020, the prevailing narrative was one of acute…[...]

August 29, 2025 | John Murphy | Leave a Comment

Exploration of Intersections and Divergences of Long COVID and Chronic Fatigue Syndrome

Joao A. Kouyoumdjian • Leticia A. Yamamoto • Carla R. Graca, DOI: 10.7759/cureus.90607 Abstract Background: Fatigue is the most common symptom of Long COVID (LC), defined by persistent or newly emerging symptoms that develop at least three…[...]

August 13, 2025 | John Murphy | Leave a Comment

Chronic fatigue sufferers have different genes, study finds

Financial Times‘ Groundbreaking’ research finds ‘genetic signals’ for the long-stigmatized illness People with chronic fatigue syndrome have a different genetic profile to the general population, with DNA variations in their…[...]

August 10, 2025 | John Murphy | Leave a Comment

Pediatric gastrointestinal tract outcomes during the postacute phase of COVID-19

Zhang, D; Stein, R; Lu, Y; et al.; Researching COVID to Enhance Recovery (RECOVER) Initiative, JAMA Network Open Abstract Importance: The profile of gastrointestinal (GI) tract outcomes associated with the postacute and…[...]