Category: Immune System

mRNA SARS-CoV-2 Vaccination Before vs During Pregnancy and Omicron Infection Among Infants

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Orlanda Goh, MB, BS, MPH1,2,3;  Deanette Pang, BSocSc4;  Janice Tan, BSocSc4; et alDavid Lye, MB, BS5,6,7,8;  Chia Yin Chong, MMed; Benjamin Ong, MMed4,7; Kelvin Bryan Tan, PhD4,11,12; Chee Fu Yung, MBChB5,9,10,11 JAMA Network Open. 2023;6(11):e2342475. doi:10.1001/jamanetworkopen.2023.42475 Key Points Question  Is maternal vaccination associated with a lower risk of infection with Omicron SARS-CoV-2 variants, including XBB, among infants up to 6 months of age? Findings  In this national population-based cohort study of 7292 infants aged 6 months or younger […]

CDC Claims On Vaccination And Natural Immunity Made Without Seeing Underlying Data: FOIA Document

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NOV 17, 2023 – Authored by Hans Mahncke via The Epoch Times  In a new Freedom of Information Act (FOIA) response, the Centers for Disease Control and Prevention (CDC) now admits that it recommended COVID-19 vaccines for people who had recovered from COVID-19 despite the fact that CDC subject matter experts didn’t have access to the […]

Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

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Akshita Gupta,1,2 Angelina Konnova,1,2 Mathias Smet,1,2 Matilda Berkell,1,2 Alessia Savoldi,3 Matteo Morra,3 Vincent Van averbeke,1 Fien H.R. De Winter,1 Denise Peserico,4 Elisa Danese,4 An Hotterbeekx,1 Elda Righi,3 mAb ORCHESTRA working group,5 Pasquale De Nardo,3 Evelina Tacconelli,3 Surbhi Malhotra-Kumar,2 and Samir Kumar-Singh1,2 Journal of Clinical Investigation 10.1172/JCI166032 Abstract Background. The role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored. Methods. In a prospective, […]

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs

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Jean-Laurent Casanova1,2,3,4,5 and Mark S. Anderson6,7, Published February 1, 2023 – More infoView PDF Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were discovered in 2006, but not […]

Does the SARS-CoV-2 spike really have an Achilles heel?

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Shiv Pillai, Published , 2023 – More infoView PDF , 10.1172/JCI168080 Abstract The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an anti-SARS-CoV-2 spike antibody, isolated from a […]

No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

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Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 – September 1, 2023. Reference information: J Clin Invest. 2023;133(17):e171742. https://doi.org/10.1172/JCI171742. To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune […]

Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses

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Cutaneous Basophil Hypersensitivity Response after Skin-Test Antigen Injection. Philip W. Askenase, M.D., Yale University School of Medicine, New Haven, CT In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the […]

Why don’t most children get severely sick from COVID? Nose and immune response offer clues

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By David Olson, October 23, 2023 10:50 Newsday Young children rarely get severely ill from COVID-19 because their immune systems seem to block the coronavirus from spreading beyond the nose, a new study suggests, and experts say kids’ response to the virus could help develop a more effective vaccine for people of all ages. Scientists long […]

The real data behind the new COVID vaccines the White House is pushing

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By  Marty Makary and Tracy Beth Høeg Published Sep. 14, 2023 What if I told you one in 50 people who took a new medication had a “medically attended adverse event” and the manufacturer refused to disclose what exactly the complication was — would you take it? And what if the theoretical benefit was only transient, lasting […]

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines 

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Sandhya Bansal; Sudhir Perincheri; Timothy Fleming; Christin Poulson;Brian Tiffany;Ross M. Bremner; Thalachallour Mohanakumar  J Immunol (2021) 207 (10): 2405–2410.https://doi.org/10.4049/jimmunol.2100637 Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity. To determine the mechanism, we analyzed the kinetics […]