Breathing difficulties after covid-19: a guide for primary care

BMJ 2023; 381 doi: , June 2023) Cite this as: BMJ 2023;381:e074937, Rachael Evans, Anton Pick, et. al. What you need to know Around one in four adults who were hospitalised with covid-19 and one in six who were not hospitalised experience persistent breathing difficulties beyond four weeks after SARS-CoV-2 infection,12 and a cohort study in China demonstrated that breathlessness can persist […]

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Sandra Lopez-Leon, Talia Wegman-Ostrosky, Nature Scientific Reports volume 11, Article number: 16144 (2021)  Abstract COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st […]

Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms

Authors: Qing Han 1,Bang Zheng 2,3,4,*,Luke Daines 2 and Aziz Sheikh  Pathogens 2022, 11(2), 269;, Published: 19 February 2022 Emerging and/or Zoonotic Viral Infections) Abstract Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms persisting for at least […]

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis

Shin Jie Yong PMID: 33538586 DOI: 10.1021/acschemneuro.0c00793 ACS Chem Neuroscience . 2021 Feb 17;12(4):573-580. doi: 10.1021/acschemneuro.0c00793. Epub 2021 Feb 4. Abstract Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal and cardiac problems, cognitive impairments, myalgia, and others. While the possible causes of long-COVID include […]

Risk of new‐onset psychiatric sequelae of COVID‐19 in the early and late post‐acute phase

Authors: Ben Coleman, 1 , 2 Elena Casiraghi, 3 , 4 Hannah Blau, 1 Lauren Chan, 5 Melissa A. Haendel, 6 Bryan Laraway, 6 Tiffany J. Callahan, 6 Rachel R. Deer, 7 Kenneth J. Wilkins, 8 Justin Reese, 9 and Peter N. Robinson 1 , 2 World Psychiatry. 2022 Jun; 21(2): 319–320 2022 May 7. doi: 10.1002/wps.20992 PMCID: PMC9077621 PMID: 35524622 Recent publications have documented that a proportion of COVID‐19 patients develop psychiatric symptoms during or after acute infection 1 . We investigated this risk in the […]

Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Authors: Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu Ma Jowaly Schneider, et al. Published:January 12, 2022DOI: Background Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods We obtained the lung specimens from the patients […]

Characteristics of SARS-CoV-2 and COVID-19

Authors: Ben Hu, Hua Guo, Peng Zhou & Zheng-Li Shi  Nature Reviews Microbiology volume 19, pages141–154 (2021) Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we […]

The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT

Authors: Jia-Ni Zou , Liu Sun , Bin-Ru Wang , You Zou , Shan Xu, Yong-Jun Ding, Li-Jun Shen, Wen-Cai Huang, Xiao-Jing Jiang, Shi-Ming Chen  Published: March 23, 2021 Abstract The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately studied. AI-assisted chest high-resolution computed tomography (HRCT) was used to […]

Post-acute COVID-19 syndrome

Authors: Ani Nalbandian, Kartik Sehgal, Elaine Y. Wan Nature Medicine volume 27, pages601–615 (2021) Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of […]