Category: Dyspnea

POST-ACUTE SEQUELAE OF COVID-19: CHARACTERIZATION, COMORBIDITIES, AND BIOMARKERS IN A DIVERSE COHORT

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Emily Struttmann, Anish Shah, Matthew Moreida, et. al. doi: https://doi.org/10.1101/2024.06.20.24308901 Abstract Introduction Post-acute sequelae of COVID-19 (PASC) is causing a silent pandemic in the U.S. Gulf South, a part of flyover U.S. where patients are quietly withdrawing from the workforce and largely disconnected from the advocacy resources growing in more affluent regions[1]. To date, there is no clinical test to diagnose PASC […]

Pathophysiological, immunological, and inflammatory features of long COVID

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Karen Bohmwald1,2†Benjamín Diethelm-Varela1†Linmar Rodríguez-Guilarte1 , et. al., Front. Immunol., 27 February 2024, Sec. Viral Immunology, Volume 15 – 2024 | https://doi.org/10.3389/fimmu.2024.1341600 The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing substantial social and economic burdens on nations. While most of the attention and therapeutic efforts have […]

Breathing difficulties after covid-19: a guide for primary care

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BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-074937 , June 2023) Cite this as: BMJ 2023;381:e074937, Rachael Evans, Anton Pick, et. al. What you need to know Around one in four adults who were hospitalised with covid-19 and one in six who were not hospitalised experience persistent breathing difficulties beyond four weeks after SARS-CoV-2 infection,12 and a cohort study in China demonstrated that breathlessness can persist […]

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

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Sandra Lopez-Leon, Talia Wegman-Ostrosky,  et.al. Nature Scientific Reports volume 11, Article number: 16144 (2021)  Abstract COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st […]

Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms

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Authors: Qing Han 1,Bang Zheng 2,3,4,*,Luke Daines 2 and Aziz Sheikh  Pathogens 2022, 11(2), 269; https://doi.org/10.3390/pathogens11020269, Published: 19 February 2022 Emerging and/or Zoonotic Viral Infections) Abstract Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms persisting for at least […]

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis

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Shin Jie Yong PMID: 33538586 DOI: 10.1021/acschemneuro.0c00793 ACS Chem Neuroscience . 2021 Feb 17;12(4):573-580. doi: 10.1021/acschemneuro.0c00793. Epub 2021 Feb 4. Abstract Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal and cardiac problems, cognitive impairments, myalgia, and others. While the possible causes of long-COVID include […]

Risk of new‐onset psychiatric sequelae of COVID‐19 in the early and late post‐acute phase

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Authors: Ben Coleman, 1 , 2 Elena Casiraghi, 3 , 4 Hannah Blau, 1 Lauren Chan, 5 Melissa A. Haendel, 6 Bryan Laraway, 6 Tiffany J. Callahan, 6 Rachel R. Deer, 7 Kenneth J. Wilkins, 8 Justin Reese, 9 and Peter N. Robinson 1 , 2 World Psychiatry. 2022 Jun; 21(2): 319–320 2022 May 7. doi: 10.1002/wps.20992 PMCID: PMC9077621 PMID: 35524622 Recent publications have documented that a proportion of COVID‐19 patients develop psychiatric symptoms during or after acute infection 1 . We investigated this risk in the […]

Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

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Authors: Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu Ma Jowaly Schneider, et al. Published:January 12, 2022DOI:https://doi.org/10.1016/j.ebiom.2022.103812 Background Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods We obtained the lung specimens from the patients […]

Characteristics of SARS-CoV-2 and COVID-19

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Authors: Ben Hu, Hua Guo, Peng Zhou & Zheng-Li Shi  Nature Reviews Microbiology volume 19, pages141–154 (2021) Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we […]

The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT

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Authors: Jia-Ni Zou , Liu Sun , Bin-Ru Wang , You Zou , Shan Xu, Yong-Jun Ding, Li-Jun Shen, Wen-Cai Huang, Xiao-Jing Jiang, Shi-Ming Chen  Published: March 23, 2021 https://doi.org/10.1371/journal.pone.0248957 Abstract The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately studied. AI-assisted chest high-resolution computed tomography (HRCT) was used to […]