Mitochondrial Depletion and Long-COVID: Etiology, Pathophysiology, Diagnostics, and Clinical Implications

John Murphy, M.D., MPH, D.P.H., President The COVID19 Long-haul Foundation AbstractA growing body of evidence implicates mitochondrial dysfunction — including depletion of mitochondrial DNA (mtDNA), loss of mitochondrial membrane potential,…[...]

Read More

Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics

Grant McGee Talkington, Paresh Kolluru, Timothy E. Gressett, et. al., Frontiers in Neurology One lingering effect of the COVID-19 pandemic created by SARS-CoV-2 is the emergence of Long COVID (LC),…[...]

Read More

Distinguishing features of long COVID identified through immune profiling

Jon Klein, Jamie Wood, Jillian R. Jaycox, et. al., Nature volume 623, pages139–148 Abstract Post-acute infection syndromes may develop after acute viral disease1. Infection with SARS-CoV-2 can result in the development of a post-acute infection syndrome…[...]

Read More

First Diagnostic Test for Long Covid, Detecting Spike Protein in Blood, to Launch in September. Or is it ‘Long Vaccine’?

Authors{ WILL JONES 3 SEPTEMBER 2022  The first diagnostic designed to identify patients with Long Covid has received CE-IVD marking in Europe, meaning it is ready for its formal launch…[...]

Read More

Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution

2020 Jun;24(3):251-262. doi: 10.1007/s40291-020-00460-z. Walter Gottlieb Land 1 2 PMID: 32248387 PMCID: PMC7127836 DOI: 10.1007/s40291-020-00460-z Free PMC article Abstract This opinion article discusses the increasing attention paid to the role of activating damage-associated molecular patterns (DAMPs)…[...]

Read More

Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia

Review Article; Published: 17 June 2021 Authors: Walter Gottlieb Land Genes & Immunity volume 22, pages141–160 (2021 )Cite this article Abstract When surveying the current literature on COVID-19, the “cytokine storm” is considered to be…[...]

Read More