SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans


Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Nature volume 595, pages421–425 (2021) Abstract Long-lived bone marrow plasma…[...]

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns


Authors: Alessandro Sette 1 2, Shane Crotty 3 4 Abstract T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that…[...]

COVID-19 survivors may possess wide-ranging resistance to the disease


Authors: Rajee Suri rajee.suri@emory.edu Recovered COVID-19 patients retain broad and effective longer-term immunity to the disease, suggests a recent Emory University study, which is the most comprehensive of its kind…[...]

Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals


Authors: Fan Zhang, Rui Gan, Ziqi Zhen, Xiaoli Hu, Xiang Li, Fengxia Zhou, Ying Liu, Chuangeng Chen, Shuangyu Xie, Bailing Zhang, Xiaoke Wu & Zhiwei Huang Signal Transduction and Targeted Therapy volume 5, Article number: 156 (2020)  Abstract The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2…[...]

Adaptive immunity to SARS-CoV-2 and COVID-19


Authors: Alessandro Sette1,2 and Shane Crotty1,2,∗ Abstract The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the…[...]

Not just antibodies: B cells and T cells mediate immunity to COVID-19


Authors: Rebecca J. Cox & Karl A. Brokstad Nature Reviews Immunology volume 20, pages581–582 (2020) Recent reports that antibodies to SARS-CoV-2 are not maintained in the serum following recovery from the virus have caused alarm. However,…[...]