John Murphy, M.D., M.P.H., D.P.H. CEO COVID Long-haul Foundation Abstract Background Long COVID, also termed Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), is a complex multisystem disorder characterized by persistent symptoms […]
Persistent Immune Exhaustion in Post–Acute Sequelae of SARS-CoV-2 Infection
John Murphy, M.D., M.P.H., D.P.H. President Cov-19 Long-haul Foundation Immunologic Foundations, T-cell Dysfunction, and Exhaustion Signatures Abstract Importance: Post–acute sequelae of SARS-CoV-2 infection (PASC), commonly referred to as Long COVID, […]
COVID-19 infection induces long-term changes in the immune system
John Murphy, CEO COVID-19 Long-haul foundation I. Introduction: The Immune System Under Siege The immune system is a dynamic, multilayered defense network composed of innate and adaptive components, designed to […]
Persistent SARS-CoV-2 Spike Protein: Genomic Modulation, Immune Dysregulation, and Impaired Antibody Maturation
Author: John Murphy, CEO COVID 19 Long-haul Foundation Abstract The SARS-CoV-2 spike glycoprotein, central to viral entry and the target of mRNA vaccine platforms, has emerged as a persistent antigen […]
COVID-19 and immune dysregulation: Genomic pathways, clinical manifestations, and therapeutic strategies
John Murphy, CEO & President, COVID-19 Long-haul Foundation Abstract SARS-CoV-2 provokes a uniquely heterogeneous and dynamic immune response that ranges from efficient viral control to fulminant hyperinflammation and prolonged immune […]
Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations?
Christian A Koch, Journal of the Endocrine Society, Volume 8, Issue 5, May 2024, bvae043, https://doi.org/10.1210/jendso/bvae043 Commentary Approximately 5% of all individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) […]
Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination
Bornali Bhattacharjee, Peiwen Lu, Valter Silva Monteiro, et. al. doi: https://doi.org/10.1101/2025.02.18.25322379 Yale Study Reveals Shocking Truth: Spike Protein Lingers – and Grows SUMMARY COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the […]
Statistical Analysis of Multiple Vaccine Effectiveness Against COVID-19 Variants
Abstract The study aims to evaluate the association between multiple COVID-19 vaccine doses and daily confirmed cases, incorporating immune response delays to better understand vaccination efficacy. We investigated the effectiveness […]
First-Of-Its-Kind Study Explains Why Some People Don’t Get COVID-19
JUN 20, 2024 – Authored by Marina Zhang via The Epoch Times Researchers have discovered why some people remain uninfected by the COVID-19 virus—even after their nasal cavities are exposed […]
Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs
Jean-Laurent Casanova1,2,3,4,5 and Mark S. Anderson6,7, Published February 1, 2023 – More infoView PDF Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe […]