Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs

Jean-Laurent Casanova1,2,3,4,5 and Mark S. Anderson6,7, Published February 1, 2023 – More infoView PDF Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were discovered in 2006, but not […]

No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 – September 1, 2023. Reference information: J Clin Invest. 2023;133(17):e171742. https://doi.org/10.1172/JCI171742. To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune […]

Long COVID Now Looks like a Neurological Disease, Helping Doctors to Focus Treatments

The causes of long COVID, which disables millions, may come together in the brain and nervous system  Stephani Sutherland   March 1, 2023 Tara Ghormley has always been an overachiever. She finished at the top of her class in high school, graduated summa cum laude from college and earned top honors in veterinary school. She went […]

Impacts of COVID on the immune system

Authors: Lara Herrero, The Conversation Medical Xpress September 19, 2022 So you’ve had COVID and have now recovered. You don’t have ongoing symptoms and luckily, you don’t seem to have developed long COVID. But what impacts has COVID had on your overall immune system? It’s early days yet. But growing evidence suggests there are changes to […]

COVID-19 pandemic: Viral infections and Vitamin D

Authors: Nurshad Ali*Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh Optom Open Access 2022, Vol 7(3): 3DOI: 10.4172/2476-213X.1000152 Introduction Vitamin D is a steroid hormone, produced endogenously with the effect of ultraviolet radiation on the skin or available from exogenous food sources or dietary supplements. Vitamin D insufficiency is […]

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

Authors: Chansavath Phetsouphanh, David R. Darley, Daniel B. Wilson, Annett Howe, C. Mee Ling Munier, Sheila K. Patel, Jennifer A. Juno, Louise M. Burrell, Stephen J. Kent, Gregory J. Dore, Anthony D. Kelleher & Gail V. Matthews  Nature Immunology volume 23, pages210–216 (2022) June 30, 2022 Nature Immunology volume 23, pages210–216 (2022) Abstract A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer […]

Mount Sinai researchers develop a rapid test to measure immunity to COVID-19

New blood assay provides critical information for revaccination strategies in vulnerable individuals Peer-Reviewed Publication THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE Mount Sinai researchers have developed a rapid blood assay that measures the magnitude and duration of someone’s immunity to SARS-CoV-2, the virus that causes COVID-19. This test will allow large-scale monitoring […]

Why COVID-19 Is Here to Stay, and Why You Shouldn’t Worry About It

Authors: August 17, 2021 by Philippe Lemoine As many countries are going through another wave of infections, including some where the vast majority of the population has been vaccinated, many are starting to despair that we’ll never see the end of the pandemic. In this post, I will argue that, on the contrary, not only is the […]

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients

Authors: Joram Huckriede, Sara Bülow Anderberg, Albert Morales, Femke de Vries, Michael Hultström, Anders Bergqvist, José T. Ortiz-Pérez, Jan Willem Sels, Kanin Wichapong, Miklos Lipcsey, Marcel van de Poll, Anders Larsson, Tomas Luther, Chris Reutelingsperger, Pablo Garcia de Frutos, Robert Frithiof & Gerry A. F. Nicolaes  Scientific Reports volume 11, Article number: 15701 (2021) Cite this article Abstract Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to […]