Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Authors: MartinDugasa1TanjaGrote-Westrickb1UtaMerledMichaelaFontenaylmAndreas E.KremerhFrankHansesijRichardVollenbergcEvaLorentzenbShilpaTiwari-BecklerdJérômeDucheminlSyrineEllouzelMarcelVetterhJuliaFürsthPhilippSchusterkTobiasBrixaClaudia M.DenkingerfgCarstenMüller-TidoweHartmutSchmidtc…JoachimKühnb1 Highlights Does prior infection with seasonal human coronavirus OC43 protect against critical COVID-19?• Findings: In an international multi-center study inpatients without anti-HCoV OC43 NP antibodies had an increased risk of…[...]

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Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Authors: Martin Dugas 1, Tanja Grote-Westrick 2, Uta Merle 3, Michaela Fontenay 4, Andreas E Kremer 5, Frank Hanses 6, Richard Vollenberg 7, Eva Lorentzen 8, Shilpa Tiwari-Heckler 9, Jérôme Duchemin 10, Syrine Ellouze 11, Marcel Vetter 12, Julia Fürst 13, Philipp Schuster 14, Tobias Brix 15, Claudia M Denkinger 16, Carsten Müller-Tidow 17, Hartmut Schmidt 18, Phil-Robin Tepasse 19, Joachim Kühn 20 Abstract Background: The vast majority of COVID-19…[...]

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Multi-layered transcriptomic analyses reveal an immunological overlap between COVID-19 and hemophagocytic lymphohistiocytosis associated with disease severity

Authors: Lena F. Schimkea,5, Alexandre H.C. Marquesa, Gabriela Crispim Baiocchia, Caroline Aliane de Souza Pradob Dennyson Leandro M. Fonsecab , Paula Paccielli Freirea , Desirée Rodrigues Plaçab , Igor Salerno…[...]

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SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Abstract Long-lived bone marrow plasma cells (BMPCs)…[...]

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