Category: Diagnostics

Hyperglycemia in Acute COVID-19 is Characterized by Adipose Tissue Dysfunction and Insulin Resistance

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Authors: Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Rubio-Navarro A, Uhl S, Shukla AP, Goyal P, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM Abstract  COVID-19 has proven to be a metabolic disease resulting in adverse outcomes in individuals with diabetes or obesity. Patients infected with SARS-CoV-2 and hyperglycemia suffer from longer hospital stays, higher risk of […]

Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage

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Authors: Yan-Mei ChenYuanting ZhengYing YuYunzhi WangQingxia HuangFeng QianLei SunZhi-Gang SongZiyin ChenJinwen FengYanpeng AnJingcheng YangZhenqiang SuShanyue SunFahui DaiQinsheng ChenQinwei LuPengcheng LiYun LingZhong YangHuiru TangLeming ShiLi JinEdward C HolmesChen DingTong-Yu ZhuYong-Zhen Zhang Abstract COVID-19 is characterized by dysregulated immune responses, metabolic dysfunction and adverse effects on the function of multiple organs. To understand host responses to COVID-19 […]

Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

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Authors: Davide Scozzi,1Marlene Cano,2Lina Ma,2Dequan Zhou,1Ji Hong Zhu,1Jane A. O’Halloran,3Charles Goss,4Adriana M. Rauseo,3Zhiyi Liu,1Sanjaya K. Sahu,2Valentina Peritore,5Monica Rocco,6Alberto Ricci,7Rachele Amodeo,8Laura Aimati,8Mohsen Ibrahim,1,5Ramsey Hachem,2Daniel Kreisel,1Philip A. Mudd,9Hrishikesh S. Kulkarni,2,10 and Andrew E. Gelman1,11 Abstract Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict […]

C-Reactive Protein Level May Predict the Risk of COVID-19 Aggravation

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Authors: Guyi Wang 1, Chenfang Wu 1, Quan Zhang 2, Fang Wu 3, Bo Yu 1, Jianlei Lv 2, Yiming Li 4, Tiao Li 5, Siye Zhang 1, Chao Wu 6 7 8, Guobao Wu 1, Yanjun Zhong 1Affiliations expand Abstract Background: Clinical findings indicated that a fraction of coronavirus disease 2019 (COVID-19) patients diagnosed as mild early may progress to severe cases. However, it is difficult to distinguish these patients in the early stage. The present study aimed to describe the […]

Elevated level of C‐reactive protein may be an early marker to predict risk for severity of COVID‐19

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Authors: Nurshad Ali 1 The outbreak of coronavirus disease‐2019 (COVID‐19) is an emerging global health threat. The healthcare workers are facing challenges in reducing the severity and mortality of COVID‐19 across the world. Severe patients with COVID‐19 are generally treated in the intensive care unit, while mild or non‐severe patients treated in the usual isolation ward […]

The role of C-reactive protein as a prognostic marker in COVID-19

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Authors: Dominic Stringer,1Philip Braude,2Phyo K Myint,3Louis Evans,4Jemima T Collins,5Alessia Verduri,6Terry J Quinn,7Arturo Vilches-Moraga,8Michael J Stechman,9Lyndsay Pearce,10Susan Moug,11Kathryn McCarthy,12Jonathan Hewitt,13 and Ben Carter1 Abstract Background C-reactive protein (CRP) is a non-specific acute phase reactant elevated in infection or inflammation. Higher levels indicate more severe infection and have been used as an indicator of COVID-19 disease severity. However, the […]

High sensitivity troponin and COVID-19 outcomes

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Authors: Nikolaos Papageorgiou,a,bCatrin Sohrabi,aDavid Prieto Merino,c,dAngelos Tyrlis,aAbed Elfattah Atieh,aBunny Saberwal,aWei-Yao Lim,aAntonio Creta,aMohammed Khanji,aReni Rusinova,aBashistraj Chooneea,aRaj Khiani,d,eNadeev Wijesuriya,e,fAnna Chow,e,fHaroun Butt,e,fStefan Browne,e,fNikhil Joshi,e,fJamie Kay,e,fSyed Ahsan,a and Rui Providenciaa,g Abstract Background Recent reports have demonstrated high troponin levels in patients affected with COVID-19. In the present study, we aimed to determine the association between admission and peak troponin levels and […]

Clinical utility of cardiac troponin measurement in COVID-19 infection

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Authors: David C Gaze 1 2 Abstract The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission. The impact is far-reaching, with enforced social distancing and isolation, detrimental effects on individual physical activity and mental wellbeing, education in the […]

Troponin and BNP Use in COVID-19

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Mar 18, 2020 Cardiology Magazine Authors: James L. Januzzi Jr., MD, FACC What are the potential mechanisms underlying troponin elevation with COVID-19 infection? Rise and/or fall of troponin indicating myocardial injury is common among patients with acute respiratory infections and correlated with disease severity.  Abnormal troponin values are common among those with COVID-19 infection particularly […]

Cardiac Troponin-I and COVID-19: A Prognostic Tool for In-Hospital Mortality

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Authors: Baher Al Abbasi 1, Pedro Torres 1, Fergie Ramos-Tuarez 2, Nakeya Dewaswala 1, Ahmed Abdallah 1, Kai Chen 1, Mohamed Abdul Qader 1, Riya Job 1, Samar Aboulenain 1, Karolina Dziadkowiec 1, Huzefa Bhopalwala 3, Jesus E Pino 2, Robert D Chait 2 Abstract Background: The number of fatalities due to coronavirus disease 2019 (COVID-19) is escalating with more than 800,000 deaths globally. The scientific community remains in urgent need of prognostic tools to determine the probability of survival in […]